Results 61 to 70 of about 9,883,428 (297)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Response Analysis of Projectile System Under Gaussian Noise Excitation Using Path Integral Method
International Journal of Aerospace EngineeringDuring flight, projectiles are subject to uncertainties such as aerodynamic forces, wind gusts, and measurement errors; all of which significantly affect their stability and accuracy.
Liang Wang +4 more
doaj +2 more sources
Department of Applied Mathematics and Statistics newsletter, January 22, 2024 [PDF]
Newsletter of the Department of Applied Mathematics and Statistics at Colorado School of ...
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Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Statistics applied to plant micropropagation: a critical review of inadequate use
Bioscience Journal, 2018 Statistical analyses are an essential part of scientific research. Various procedures since the preparation of the experiment have an impact on the statistical procedures adopted. Therefore, a correct planning implies a precise analysis. Through sampling
Vanderley José Pereira +4 more
doaj +3 more sources
Win statistics applied to registry-based randomized clinical trials
TrialsBackground Win statistics offer an alternative approach to clinical trials that use survival analysis to analyze composite endpoints. Our objective was to re-analyze data from previously published registry-based randomized controlled trials that produced
Rebecca Rylance +7 more
doaj +1 more source
International Journal of Geo-Engineering, 2017 Slope stability monitoring and evaluating play vital role in the risk management of open cast mines. Generally, Issue of slope failure occurs at open cast mines due to undisciplined mining, impacts of weather conditions.
Ajay Kumar, Ritika Rathee
doaj +1 more source
Department of Applied Mathematics and Statistics newsletter, September 16, 2024 [PDF]
Newsletter of the Department of Applied Mathematics and Statistics at Colorado School of ...
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