Results 131 to 140 of about 593,710 (304)

Applying economic analysis to technical assistance projects [PDF]

open access: yes
The author recommends using more quantitative economic analysis in appraising technical assistance loans and loan components. After giving a brief history of tecnhical assistance and the problems commonly associated with it, he describes classifications ...
McMahon, Gary
core  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

They really, really, really don’t like to admit they made mistakes: A critical discourse analysis of appraisal in wrongful convictions

open access: yesLanguage and Cognition
Besides being unjustly incarcerated, Sabrina Butler, Kristine Bunch, Ru-el Sailor and Larry DeLisle endured various forms of police mistreatment, as detailed in a collection of transcripts from the Wrongful Conviction Podcast (WCP). Understandably enough,
Carmen Ortega-Robles   +1 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Allocution, sentencing, and viewers’ comments in YouTube-mediated trials of convicted young murderers: an appraisal-sentiment analysis

open access: yesLanguage and Semiotic Studies
Courtroom discourse, a highly conventionalized genre, integrates numerous linguistic affordances and semiotic resources. Courtroom interactions provide a rich environment for displaying power, identity, ideology, and affect.
El Attar Abeer Aly, Abdo Muhammad S.
doaj   +1 more source

From pattern appraisal to unitary appreciative inquiry - a critical reflection on the development of the unitary appreciative inquiry method [PDF]

open access: yes, 2008
Summative Assessment of the Core Module „Theoretical Developments in the Science and Art of Nursing“. The purpose of this article is to place Cowling’s unitary appreciative inquiry method in the context of nursing science and the development of unique ...
Wolfensberger, Peter
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Fine-grained analysis of aspects, sentiments and types of attitudes in restaurant reviews

open access: yesTourism & Management Studies, 2014
This paper presents a novel approach based on the Appraisal Theory to analyze user-generated, open-ended online restaurant reviews. We selected reviews (N=1100) from restaurants of two Portuguese touristic regions and focus, through content analysis ...
Marcirio Silveira Chaves   +3 more
doaj  

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