Results 201 to 210 of about 6,542,393 (249)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Comment on Ozler et al.: "Interscalene Block Versus Posterior Suprascapular Block for Postoperative Analgesia in Arthroscopic Shoulder Surgery". [PDF]

Sisli Etfal Hastan Tip Bul
Sethuraman RM, Ramesh G.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Functional outcomes and anatomy-based surgical strategy in 57 pineal region tumors. [PDF]

Surg Neurol Int
Gupta V, Gupta P.
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Evaluation of the Government indicator methodology in the Global Matrix on physical activity for children and adolescents. [PDF]

J Exerc Sci Fit
Demchenko I, Aubert S, Kuzik N, Edwards LC, Ward M, Arbour-Nicitopoulos KP, Brazo-Sayavera J, Cortinez-O'Ryan A, De Roia G, González SA, Guisihan RM, Jeon JY, Kim YS, Poh BK, Slančová TK, López-Gil JF, Ng K, Palad Y, Silva DAS, Tomaz SA, Urbański PK, Tremblay MS.   +21 more
europepmc   +1 more source

A Statistical Perspective on Transformers for Small Longitudinal Cohort Data. [PDF]

Stat Med
Farhadyar K, Hackenberg M, Ahrens K, Schenk C, Kollmann B, Tüscher O, Lieb K, Plichta MM, Reif A, Kalisch R, Wolkewitz M, Hess M, Binder H.   +12 more
europepmc   +1 more source

Penalised Spline Estimation of Covariate-Specific Time-Dependent ROC Curves. [PDF]

Stat Med
Rodríguez-Álvarez MX, Inácio V.
europepmc   +1 more source