Results 101 to 110 of about 6,634,346 (295)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Hubble Space Telescope Observations of 3200 Phaethon At Closest Approach

, 2018
We present Hubble Space Telescope observations of the active asteroid (and Geminid stream parent) 3200 Phaethon when at its closest approach to Earth (separation 0.07 AU) in 2017 December.
Agarwal, Jessica, Jewitt, David, Li, Jing, Mutchler, Max   +3 more
core   +1 more source

Stochastic inflation: Quantum phase-space approach [PDF]

Physical Review D, 1992
In this paper a quantum mechanical phase space picture is constructed for coarse-grained free quantum fields in an inflationary Universe. The appropriate stochastic quantum Liouville equation is derived. Explicit solutions for the phase space quantum distribution function are found for the cases of power law and exponential expansions.
openaire   +3 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Generation of Space Shooter Level Using Genetic Approach

Jurnal Informatika, 2019
In this article, we used genetic algorithm and geometric-based approach to generating level for 2D space shooter game. We used the defined fitness value from game designer to limit the fitness value of the genetic algorithm process.
Ahmad Hamdani, Wahyu Andhyka Kusuma
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Urban Morphology: The Significance of Urban Space History

Land
The importance of urban morphology lies with its interdisciplinary approach from architecture over history to geography. However, often enough, its scientific methods only marginally start from the urban space itself that makes morphology tangible in the
Karsten Ley
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Clinical analysis and surgical approaches for parapharyngeal space tumors

Kouqiang hemian waike zazhi
Parapharyngeal space (PPS) is a deep anatomical compartment in the head and neck region, containing critical structures such as the internal carotid artery and cranial nerves. Primary tumors in this area are relatively rare.
LI Zihui, LI Fuyan, SUN Guowen
doaj   +1 more source

On (pre-) approach spaces within convergence approach spaces

The purpose of this note is to illustrate a parallel between (pre)topologies when seen among convergence spaces and (pre)approach spaces when seen among convergence approach spaces, that appears to be a more complete parallel than in the traditional presentation of these approach structures.
openaire   +2 more sources