Results 121 to 130 of about 6,634,346 (295)
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
An economical approach to space power systems [PDF]
Projected energy demand for all NASA, DoD and civil missions for the time span 1981 to 1995 are illustrated. Typical energy cost range from about $300 to $2000 per kW-hr, with an average of about $800 per kW-hr for long-duration missions. At these levels,
Teren, F.
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Space Security: An Approach from the Copenhagen School
Acta Politica PolonicaThe first emergence of the concept of space security came to the fore with the beginning of access to space. As the competition between the USA and the USSR spread to space, space formed the background of ideological conflict.
Neslihan Topcu Alparaslan
doaj +1 more source
An AI approach for scheduling space-station payloads at Kennedy Space Center [PDF]
The Payload Processing for Space-Station Operations (PHITS) is a prototype modeling tool capable of addressing many Space Station related concerns. The system's object oriented design approach coupled with a powerful user interface provide the user with ...
Castillo, D. +3 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
On a Bohmian Structural Approach without Space Fundamentality
Análisis FilosóficoIn recent years, there has been a controversial debate in the literature regarding the choice among many interpretations of quantum mechanics.
Jorge Manero
doaj +1 more source