Results 71 to 80 of about 6,634,346 (295)

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The Actualisation of Regional Capacity Educational Space Based on Cluster Interaction: The Aspect of Formation of Training Health Culture

open access: yesОбразование и наука, 2019
Introduction. Secondary schools are the only social institution through which the entire child population passes. This suggests that the general education system is the most important link in the socialisation of an individual, where a health culture is ...
V. A. Fedorov, K. V. Chedov
doaj   +1 more source

An Innovative Approach of N-Soft Quotient Topological Space

open access: yesAdvances in Materials Science and Engineering, 2022
In the many approaches to soft set theory, the theory of N-soft topological space is a key component of studying topology. The notions of soft mapping in N-soft topological space as well as a novel notion of N-soft continuous mapping, N-soft quotient ...
G. Kabin Antony   +3 more
doaj   +1 more source

Microscopic Approach to Analyze Solar-Sail Space-Environment Effects

open access: yes, 2008
Near-sun space-environment effects on metallic thin films solar sails as well as hollow-body sails with inflation fill gas are considered. Analysis of interaction of the solar radiation with the solar sail materials is presented.
Abramov   +22 more
core   +1 more source

Approaching Economic Spaces

open access: yes, 2021
Archaeometric ceramic analysis has a long tradition. The work presented here by a research group of the Excellence Cluster Topoi focuses on the relationships between project design, methods utilized, and achieved results in focus. The concepts of the described projects were developed together in the group and are presented and discussed in a ...
openaire   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Discrete phase-space approach to mutually orthogonal Latin squares

open access: yes, 2014
We show there is a natural connection between Latin squares and commutative sets of monomials defining geometric structures in finite phase-space of prime power dimensions.
de Guise, Hubert   +3 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

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