Results 51 to 60 of about 4,599,788 (307)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Community Development: A Shift in Thinking Towards Heutagogy [PDF]
, 2014 As a result of the distinct socio-economic changes that UK society has faced in over recent years more specific community health development approaches to curricula delivery are required to ensure the provision of effective methods and approaches to ...
Halsall, Jamie, Snowden, Michael
core
Satellite-based delivery of educational content to geographically isolated communities: A service based approach [PDF]
, 2007 Enabling learning for members of geographically isolated communities presents benefits in terms of promoting regional development and cost savings for governments and companies.
B Hall +13 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Aspekti Publìčnogo Upravlìnnâ, 2017 The article contains a brief description of the Community-led local development approach (local development under the leadership of the community, CLLD) and the main purpose of its use in the European Union.
Y. G. Udod
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Preventing Chronic Disease, 2008 The Community Health Status Indicators Project (CHSI) 2008 provides 16-page reports for the 3141 counties in the United States, each of which includes more than 300 county-specific data items related to chronic and infectious diseases, birth ...
Marilyn Metzler, RN +7 more
doaj
Healthy Valleys : reversing decline in eight rural communities [PDF]
, 2007 Healthy Valleys is a community focused health improvement initiative and our operating principles are our strength – we adopt a community development approach, we are flexible, responsive to communities, effective and innovative.
Coburn, Annette, Wallace, David
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source