Results 1 to 10 of about 3,103,579 (100)

The human gut microbiota contributes to type-2 diabetes non-resolution 5-years after Roux-en-Y gastric bypass

open access: yesGut Microbes, 2022
Roux-en-Y gastric bypass (RYGB) is efficient at inducing drastic albeit variable weight loss and type-2 diabetes (T2D) improvements in patients with severe obesity and T2D.
Jean Debédat   +19 more
doaj   +1 more source

A deep-learning approach for online cell identification and trace extraction in functional two-photon calcium imaging

open access: yesNature Communications, 2022
Processing of two-photon calcium imaging data is generally time-consuming, especially for large fields of view. Here, the authors present CITE-On, a tool based on a convolutional neural network, enabling online automatic cell identification, segmentation,
Luca Sità   +6 more
doaj   +1 more source

Latent dirichlet allocation for double clustering (LDA-DC): discovering patients phenotypes and cell populations within a single Bayesian framework

open access: yesBMC Bioinformatics, 2023
Background Current clinical routines rely more and more on “omics” data such as flow cytometry data from host and microbiota. Cohorts variability in addition to patients’ heterogeneity and huge dimensions make it difficult to understand underlying ...
Elie-Julien El Hachem   +2 more
doaj   +1 more source

Functional alterations and predictive capacity of gut microbiome in type 2 diabetes

open access: yesScientific Reports, 2023
The gut microbiome plays a significant role in the development of Type 2 Diabetes Mellitus (T2DM), but the functional mechanisms behind this association merit deeper investigation. Here, we used the nanopore sequencing technology for metagenomic analyses
Nihar Ranjan Dash   +8 more
doaj   +1 more source

A curated gene and biological system annotation of adverse outcome pathways related to human health

open access: yesScientific Data, 2023
Adverse outcome pathways (AOPs) are emerging as a central framework in modern toxicology and other fields in biomedicine. They serve as an extension of pathway-based concepts by depicting biological mechanisms as causally linked sequences of key events ...
Laura Aliisa Saarimäki   +6 more
doaj   +1 more source

Terra incognita of vitality problem: Open issues. Part 2 [PDF]

open access: yesИзвестия Саратовского университета. Новая серия: Акмеология образования. Психология развития, 2021
The relevance of studying resilience is among other things conditioned by faster evolution of social objects, increase in general uncertainty, lack of stability, complexity and ambiguity of the dynamics of their state, which, in their turn, lead to an ...
Vladimir A. Tolochek
doaj   +1 more source

Knowledge management of pomelo production system in Northeast Thailand: A case study of the pomelo farmer group in Ban Thaen district [PDF]

open access: yesForest and Society, 2018
In Thailand pomelo is a fruit tree that has long been grown in the central region particularly in Nakhon Chai Si district, Nakhon Pathom province where soil is relatively fertile and has conditions of sufficient water resources.
Kanchana Duangta   +2 more
doaj   +1 more source

Model of pedagogical support of increasing the level of self-organisation in students [PDF]

open access: yesИзвестия Саратовского университета. Новая серия: Акмеология образования. Психология развития, 2021
The article presents theoretical analysis of the phenomenon of self-organization and its definition and introduces the structural-functional model of pedagogical support for increasing the level of students’ self-organization.
Svetlana A. Kosareva
doaj   +1 more source

Characterization of the Gut Microbiota in Individuals with Overweight or Obesity during a Real-World Weight Loss Dietary Program: A Focus on the Bacteroides 2 Enterotype

open access: yesBiomedicines, 2021
Background: Dietary intervention is a cornerstone of weight loss therapies. In obesity, a dysbiotic gut microbiota (GM) is characterized by high levels of Bacteroides lineages and low diversity.
Rohia Alili   +9 more
doaj   +1 more source

Protein supplementation during an energy-restricted diet induces visceral fat loss and gut microbiota amino acid metabolism activation: a randomized trial

open access: yesScientific Reports, 2021
Interactions between diet and gut microbiota are critical regulators of energy metabolism. The effects of fibre intake have been deeply studied but little is known about the impact of proteins.
Pierre Bel Lassen   +13 more
doaj   +1 more source

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