Results 101 to 110 of about 11,867,792 (283)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Theory and Practice of an Assessment of the External Economic Safety of the State Теория и практика оценки внешнеэкономической безопасности государства [PDF]

Problemi Ekonomiki, 2011
In article the essence of category the external economic safety is considered. Existing approaches to an assessment of the external economic safety of the state are analyzed.
Khaustova Viktoriya Ye., Grigorova-Berenda Larisa I.   +1 more
doaj  

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Approaches and indications in laparoscopic choledoscopy

Journal of Mind and Medical Sciences
Objectives. Up to 20% of patients with biliary lithiasis have bile duct stones, which are asymptomatic in 50% of cases. The aim of the study was to evaluate the role of choledoscopy in extracting stones from the main bile ducts.
Iulian Slavu, Raluca Tulin, Ileana Dima, Alexandru Dogaru, Florin Filipou, Bogdan Socea, Anca Monica Oprescu-Macovei, Adrian Tulin   +7 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Approaches for prevention of mother-to-child transmission of HIV services during coronavirus disease 2019

Health SA Gesondheid: Journal of Interdisciplinary Health Sciences
Background: During the coronavirus disease 2019 (COVID-19) pandemic, there was a reduction in access to prevention of mother-to-child transmission (PMTCT) of human Immunodeficiency virus (HIV) services globally, yet this programme is critical for ...
Livhuwani Tshivhase, Florence M.Q. Setshedi, Idah Moyo   +2 more
doaj   +1 more source

Multiple Approaches to Absenteeism Analysis [PDF]

, 1996
Absenteeism research has often been criticized for using inappropriate analysis. Characteristics of absence data, notably that it is usually truncated and skewed, violate assumptions of OLS regression; however, OLS and correlation analysis remain the ...
Sturman, Michael C.
core   +1 more source

Participatory Approaches

, 2013
This chapter aims to describe the diversity of participatory approaches in relation to social simulations, with a focus on the interactions between the tools and participants. We consider potential interactions at all stages of the modelling process: conceptual design; implementation; use; and simulation outcome analysis.
Barreteau, Olivier, Bots, Pieter, Daniell, Katherine Anne, Etienne, Michel, Perez, Pascal, Barnaud, Cécile, Bazile, Didier, Becu, Nicolas, Castella, Jean-Christophe, Daré, William's, Trébuil, Guy   +10 more
openaire   +7 more sources