Results 231 to 240 of about 11,867,792 (283)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Decision-Making Approaches Used to Limit Potentially Nonbeneficial Life-Prolonging Interventions.

JAMA Netw Open
Batten JN, Weiss Goitiandia S, Axelrod JK, Chernicoff HO, Nichol AA, Pereira LM, Blythe JA, Kruser JM, Dzeng EW.   +8 more
europepmc   +1 more source

Psychotherapy for complex post-traumatic stress disorder: efficacy and therapeutic factors. [PDF]

Front Psychol
Katalan C, Unterrainer HF, Gelo OCG.
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Is direct anterior approach associated with a compromise of femoral stem survival after total hip arthroplasty? A regional registry-based analysis. [PDF]

Eur J Orthop Surg Traumatol
Niccolò S, Manuele MG, Barbara B, Paolo M, Marilina A, Alberto DM, Cesare F.   +6 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Methods for Prioritizing Causal Genes in Molecular Studies of Human Disease: The State of the Art. [PDF]

Genet Epidemiol
Patasova K, Sedaghati-Khayat B, Knevel R, Cordell HJ, Pratt AG.   +4 more
europepmc   +1 more source

Reducing Health Inequities in Australia: The Role of Place-Based Action and Spatial Data Infrastructure. [PDF]

Health Promot J Austr
Olsen JR, Robinson M, Corcoran J, McDaid L.   +3 more
europepmc   +1 more source

Artificial Intelligence in <i>ALK</i>-Rearranged NSCLC: Forecasting Response and Resistance. [PDF]

Cancers (Basel)
Koulouris A, Tsagkaris C, Kalaitzidis K, Tsakonas G, Mountzios G.   +4 more
europepmc   +1 more source

The 'equity turn' and bereavement: From rhetoric to realisation. [PDF]

Palliat Care Soc Pract
Bindley K.
europepmc   +1 more source