Results 61 to 70 of about 85,861,786 (250)

Developmentally Guided Differentiation of Ventral Midbrain Dopaminergic Cells Validated in Proteopathy‐Based Parkinson's Disease Models

Advanced Science, EarlyView.
A developmentally guided protocol reproducibly specifies EN1‐positive ventral midbrain dopaminergic (vmDA) progenitors from human pluripotent stem cells and yields functional vmDA neurons. Optogenetic induction of α‐synuclein aggregation elicits selective degeneration of TH‐positive neurons in 2D cultures and 3D neurospheroids, while transplanted ...
Heechang Moon, Heejeong Kim, Elliot H. Lee, Hanseul Kim, Ji Hun Kim, Huisu Jeong, Jiwon Cheon, Ga Ram Jeong, Byoung Dae Lee, Jae‐Won Cho, Soo‐Jin Oh, Yunjong Lee, Yohan Oh   +12 more
wiley   +1 more source

Effects of gestational age at birth on cognitive performance : a function of cognitive workload demands [PDF]

, 2013
Objective: Cognitive deficits have been inconsistently described for late or moderately preterm children but are consistently found in very preterm children.
Jaekel, Julia, Dieter Wolke, Julia Jaekel (415253), Nicole Baumann (415254), Wolke, Dieter, Dieter Wolke (415255), Baumann, Nicole, Julia Jaekel, Nicole Baumann, Jaekel Julia, Baumann Nicole, Wolke Dieter   +11 more
core   +2 more sources

A Spatiotemporal Single‐Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects

Advanced Science, EarlyView.
Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang, Lun Zhu, Ze Sun, Ruolin Jia, Ziming Wang, Jiayao Zhao, Bohao Liu, Haiqing Xiong, Xiaowei Yu, Yanzhu Yue   +9 more
wiley   +1 more source

Comparisons of mortality and pre-discharge respiratory outcomes in small-for-gestational-age and appropriate-for-gestational-age premature infants

BMC Pediatrics, 2004
Background There are differences in the literature regarding outcomes of premature small-for-gestational-age (SGA) and appropriate-for gestational-age (AGA) infants, possibly due to failure to take into account gestational age at birth.
Sharma Puneet, McKay Kathleen, Rosenkrantz Ted S, Hussain Naveed   +3 more
doaj   +1 more source

Diagnostic Accuracy of Doppler Ultrasound in Predicting Perinatal Outcome in Appropriate for Gestational Age Fetuses: A Prospective Study

, 2020
To elucidate the role of Doppler ultrasound in predicting perinatal outcome in appropriate for gestational age (AGA) fetuses at ...
Mappa, Ilenia, Scambia, Giovanni, Gustapane, Sarah, Bascietto, Francesca, Liberati, Marco, Manzoli, Lamberto, Flacco, Maria Elena, Nappi, Luigi, Rizzo, Giuseppe, Familiari, Alessandra, D'Antonio, Francesco, Buca, Danilo, Acuti Martellucci, Cecilia, Leombroni, Martina, Rizzo G, Flacco ME, Gustapane S, Scambia G., Buca D, Manzoli L, Liberati M, Acuti Martellucci C, Scambia G, Leombroni M, Bascietto F, Nappi L, Familiari A, Mappa I, Familiari A., D'Antonio F.   +29 more
core   +1 more source

Early‐Life Manganese Overexposure Activates Microglial Phagocytosis through the YY1/TREM2 Axis Leading to Hippocampal Synaptic Remodeling in Mice

Advanced Science, EarlyView.
Early‐life manganese exposure induces behavioral deficits and aberrant hippocampal synaptic remodeling by enhancing microglial phagocytosis in young adult male mice. Mechanistically, manganese promotes Yin Yang 1 (YY1)/triggering receptor expressed on myeloid cells 2 (TREM2) signaling through enhanced HIF1α‐mediated transcription and suppressed SMURF2 ...
Keyu Chen, Bin He, Kuan Liu, Zhuo Ma, Bin Xu   +4 more
wiley   +1 more source

Bronchopulmonary dysplasia in neonates born to mothers with preeclampsia: Impact of small for gestational age. [PDF]

PLoS ONE, 2018
BACKGROUND AND OBJECTIVES:Small for gestational age and preeclampsia have both been described as risk factors for bronchopulmonary dysplasia in preterm neonates, but their respective role in the occurrence of bronchopulmonary dysplasia is debated.
Pauline Dravet-Gounot, Héloïse Torchin, François Goffinet, Marie-Stéphanie Aubelle, Mayass El Ayoubi, Claire Lefevre, Pierre-Henri Jarreau, Elodie Zana-Taïeb   +7 more
doaj   +1 more source

Uric acid levels in gestational hypertensive women predict preeclampsia and outcome of small-for-gestational-age infants

, 2019
Objective: This study aims to ascertain whether serum uric acid is a suitable predictor of preeclampsia and/or the delivery of small-for-gestational-age infants for women with gestational hypertension.
Xiaobo Zhao (123002), Sophia Twum Frempong (7462643), Tao Duan (28891)   +2 more
core   +1 more source

Structural Control of Stromal‐Immune Coupling by COL24A1 Underlies Pregnancy Maintenance

Advanced Science, EarlyView.
COL24A1 emerges as a collagen‐associated regulator of maternal‐fetal interface homeostasis. Its deficiency promotes a maladaptive TIMP1‐high stromal state, impaired ECM turnover, collagen accumulation, and stromal–immune dysregulation, contributing to pregnancy loss.
Teng Wu, Lingling Xie, Wenyi Liu, Hanjie Mo, Chengshu Xie, Jing Tang, Zhaorui Wang, Peixuan Lan, Jianping Zhang, Jie Gao, Qionglan Tang, Chunwei Cao, Hui Chen   +12 more
wiley   +1 more source

K-Mean Clustering of intra-uterine growth retarded (IUGR) and appropriate for gestational age (AGA) subjects.

, 2015
K-Mean Clustering of intra-uterine growth retarded (IUGR) and appropriate for gestational age (AGA) subjects.
Massimo Buscema (444588), Enzo Grossi (50473), Maria E. Street (336605), Luisa Montanini (694902)   +3 more
core   +1 more source