Results 191 to 200 of about 808,804 (331)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Effective descriptions of bosonic systems can be considered complete. [PDF]

Nat Commun
Arzani F, Booth RI, Chabaud U.
europepmc   +1 more source

Harnessing Fpga and Approximate Computing for Efficient Mea Signal Processing in Neuroscience

Falah Awwad, Mohammad Hassan, Osman Hasan   +2 more
openalex   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Estimation of (co)variance components for very large datasets and complex single-step genomic models. [PDF]

Genet Sel Evol
Bermann M, Legarra A, Aguilar I, Alvarez-Munera A, Misztal I, Lourenco D.   +5 more
europepmc   +1 more source

Approximate Computing in High-Level Synthesis: From Survey to Practical Implementation

Benjamin Carrion Schafer, Baharealsadat Parchamdar   +1 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Urban flood disaster prevention, control, and rescue using edge computing and the resilience concept. [PDF]

Sci Rep
Shuiquan L, Binqing Z, Tianjiao D, Mingyue G, Yashi P, Yuanshun W, Yiqi L.   +6 more
europepmc   +1 more source

Approximating cutnorm: A robust method to compute distance between dense graphs for prediction and interpretation

, 2018
Ping-Ko Chiu
openalex   +1 more source

Hardness of computing and approximating predicates and functions with leaderless population protocols

, 2018
Amanda Belleville, David Doty, David Soloveichik   +2 more
openalex   +2 more sources