Results 81 to 90 of about 2,109,815 (284)

Application of machine learning to viscoplastic flow modeling

, 2018
We present a method to construct reduced-order models for duct flows of Bingham media. Our method is based on proper orthogonal decomposition (POD) to find a low-dimensional approximation to the velocity and artificial neural network to approximate the ...
Koroteev, D., Muravleva, E., Oseledets, I.   +2 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Research on Robust and Adaptive Learned Approximate Query-Processing Method [PDF]

Jisuanji gongcheng
Owing to the significant latency of exact queries on large-scale datasets, Approximate Query-Processing(AQP) techniques are typically applied to online analytical processing to return query results within interactive timescales with minimal error.
Yimeng QIAO, Yinan JING, Hanbing ZHANG
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

THE APPROXIMATE SOLUTION FOR PLATES USING MODIFIED RAYLEIGH-RITZ METHOD

International Journal for Computational Civil and Structural Engineering, 2017
For thin elastic plates of arbitrary shape with a smooth pinched or hinged contour based on the modified Rayleigh-Ritz method, explicit expressions are obtained for the approximate values of the maximum deflection from a uniformly distributed load, the ...
Gaik A. Manuylov
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

The Scatman: an approximate method for fast wide-angle scattering simulations. [PDF]

J Appl Crystallogr, 2022
Colombo A, Zimmermann J, Langbehn B, Möller T, Peltz C, Sander K, Kruse B, Tümmler P, Barke I, Rupp D, Fennel T.   +10 more
europepmc   +1 more source

Developing Clean Technology through Approximate Solutions of Mathematical Models [PDF]

, 2012
In this paper, the role of mathematical modeling in the development of clean technology has been considered. One method each for obtaining approximate solutions of mathematical models by ordinary differential equations and partial differential ...
Anake, T. A.
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source