IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Novel Endoscopic Closure of Iatrogenic Hypopharyngeal Perforations Using Through-the-Scope Tissue Approximation Clips. [PDF]
Ramamurthy P, Zakharia K.
europepmc +1 more source
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
Flow-Based Surrogates for High-Dimensional Likelihoods in Experimental Neutrino Physics
Baz ME +3 more
europepmc +1 more source
First Order Non-Instantaneous Corrections in Collisional Kinetic Alignment Models. [PDF]
Kanzler L, Moschella C, Schmeiser C.
europepmc +1 more source
Structural Entanglement from Interaction-Induced Fixed Points. [PDF]
Gunji YP, Khrennikov A.
europepmc +1 more source
Exactly Factorized Molecular Kohn-Sham Density Functional Theory. [PDF]
Dupuy L, Lasorne B, Fromager E.
europepmc +1 more source
Intrinsic Plasticity-Driven Neuroadaptive Asymptotic Tracking Control for a Class of Uncertain Robotic Manipulators. [PDF]
Chen Q, Tan X, Hou S, Qing M, Li Z.
europepmc +1 more source
Correction: Correlation study: electrical impedance-based approximation of knee joint angle and extensor strength during concentric knee extension. [PDF]
Thönes JP +5 more
europepmc +1 more source

