Results 41 to 50 of about 30,959 (260)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin +2 more
wiley +1 more source
Expansion of the Kullback-Leibler Divergence, and a New Class of Information Metrics
Axioms, 2017 Inferring and comparing complex, multivariable probability density functions is fundamental to problems in several fields, including probabilistic learning, network theory, and data analysis.
David J. Galas +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
A method for the approximation of functions defined by formal series expansions in orthogonal polynomials [PDF]
Mathematics of Computation, 1969 An algorithm is described for numerically evaluating functions defined by formal (and possibly divergent) series as well as convergent series of orthogonal functions which are, apart from a factor, orthogonal polynomials. When the orthogonal functions are polynomials, the approximations are rational functions.
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FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Approximate observability of infinite dimensional bilinear systems using a Volterra series expansion [PDF]
Systems & Control Letters, 2015 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Lingzhong Guo +3 more
openaire +3 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Multi-parameter approximation of stress field in a cracked specimen using purpose-built Java applications [PDF]
Fracture and Structural Integrity, 2015 A quality of multi-parameter approximation of the stress and displacement fields around a crack tip in a non-brittle material test specimen is studied in the paper. The stress field approximation using Williams power series is intended to be utilized for
V. Veselý +5 more
doaj +2 more sources
The Rational Approximation of Functions which are Formally Defined by a Power Series Expansion [PDF]
Mathematics of Computation, 1960 1. Introduction. The advent of high speed digital computers and the consequent intensification of interest in the study of numerical analysis has caused considerable attention to be paid to the problem of obtaining approximation formulas for functions which occur in the theory of mathematical physics.
openaire +2 more sources