Results 81 to 90 of about 10,004 (246)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Beyond Belief Propagation: Cluster-Corrected Tensor Network Contraction with Exponential Convergence
PRX QuantumTensor network contraction on arbitrary graphs is a fundamental computational challenge with applications ranging from quantum simulation to error correction.
Siddhant Midha, Yifan F. Zhang
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
An approximate analytical solution of Richards equation with finite boundary
Boundary Value Problems, 2017 We apply a series expansion technique to estimate the water content distribution and front position in finite boundary conditions. We derive an approximate analytical solution of the Richards equation (RE) for the horizontal infiltration problem.
Xi Chen, Ying Dai
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IEEE Access, 2020 This paper is concerned with performance analysis for bounded persistent disturbances of continuous-time linear time-invariant (LTI) systems. Such an analysis can be done by computing the L∞-induced norm of continuous-time LTI systems since it ...
Jung Hoon Kim +2 more
doaj +1 more source
Wavelet series expansion in Hardy spaces with approximate duals
Analysis MathematicaIn this paper, we provide sufficient conditions for the functions $ψ$ and $ϕ$ to be the approximate duals in the Hardy space $H^p(\mathbb{R})$ for all ...
Hur, Y., Lim, H.
openaire +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
MathematicsA variety of methods that provide approximate piecewise- analytical solutions to initial-value problems governed by scalar, nonlinear, first-order, ordinary differential equations is presented.
Juan I. Ramos
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Observation of vibrating systems at different time instants
Electronic Journal of Qualitative Theory of Differential Equations, 2014 In this paper, we obtain new observability inequalities for the vibrating string. This work was motivated by a recent paper of A. Szijártó and J.
Ambroise Vest
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