Results 21 to 30 of about 565,632 (199)

Density of rational points on isotrivial rational elliptic surfaces [PDF]

, 2011
For a large class of isotrivial rational elliptic surfaces (with section), we show that the set of rational points is dense for the Zariski topology, by carefully studying variations of root numbers among the fibers of these surfaces.
Anthony Várilly-Alvarado, Colliot-Thélène, Deligne, Iwaniec, Kollár, Manduchi, Mazur, Neukirch, Rohrlich, Rohrlich, Serre, Shioda, Silverman, Silverman, Tate   +14 more
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

On stability of the three-dimensional fixed point in a model with three coupling constants from the $\epsilon$ expansion: Three-loop results

, 1998
The structure of the renormalization-group flows in a model with three quartic coupling constants is studied within the $\epsilon$-expansion method up to three-loop order.
A. I. Mudrov, B. N. Shalaev, B. V. Shabat, D. Mukamel, D. Mukamel, D. Mukamel, D. Mukamel, G. A. Baker, J. A. Lipa, J. C. Le Guillou, J. Sak, K. A. Cowley, K. B. Varnashev, K. B. Varnashev, K. De’Bell, L. S. Goldner, N. A. Shpot, N. A. Shpot   +17 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Chaotic behavior and damage spreading in the Glauber Ising model - a master equation approach [PDF]

, 1996
We investigate the sensitivity of the time evolution of a kinetic Ising model with Glauber dynamics against the initial conditions. To do so we apply the "damage spreading" method, i.e., we study the simultaneous evolution of two identical systems ...
A. Coniglio, A. Kauffman, B. Derrida, B. Derrida, B. Derrida, F. A. Tamarit, F. Wang, F. Wang, G. Le Caër, G. Le Caër, H. E. Stanley, H. G. Schuster, I. A. Campbell, J. S. Langer, O. Gollinelli, P. C. Hohenberg, P. Grassberger, P. Grassberger, P. Grassberger, S. C. Glotzer, T. Vojta, T. Wappler, Thomas Vojta, U. Costa   +23 more
core   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

On the viability of the shearing box approximation for numerical studies of MHD turbulence in accretion disks

, 2008
Most of our knowledge on the nonlinear development of the magneto-rotational instability (MRI) relies on the results of numerical simulations employing the shearing box (SB) approximation. A number of difficulties arising from this approach have recently
Balbus, Balbus, Balbus, Balbus, Blackman, Boldyrev, Brandenburg, Cattaneo, Cattaneo, Chandrasekhar, Coppi, Fromang, Fromang, Gammie, Gardiner, Goldreich, Goodman, Hawley, Hawley, Hawley, Hollerbach, Hughes, Ji, King, Knobloch, Lesur, Liu, Liu, Lynden-Bell, Noguchi, O. M. Umurhan, O. Regev, Oran, Prendergast, Psaltis, Rincon, Rüdiger, Sano, Sano, Sano, Schekochihin, Schekochihin, Schekochihin, Shakura, Shu, Sisan, Stefani, Stone, Szklarski, Toomre, Umurhan, Umurhan, Umurhan, Velikhov   +53 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source