Results 51 to 60 of about 565,632 (199)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Influence of through-flow on linear pattern formation properties in binary mixture convection

, 1996
We investigate how a horizontal plane Poiseuille shear flow changes linear convection properties in binary fluid layers heated from below. The full linear field equations are solved with a shooting method for realistic top and bottom boundary conditions.
A. Bers, A. C. Newell, A. E. Deane, A. La Porta, Ch. Jung, D. Bensimon, D. Gutkowicz-Krusin, D. Gutkowicz-Krusin, D. P. Chock, E. Kaplan, E. Knobloch, E. Knobloch, E. Moses, G. W. T. Lee, G. Zimmermann, G. Zimmermann, H. B. Squire, H. Gao, H. R. Brand, H. W. Müller, H. W. Müller, H. W. Müller, H. Yahata, H. Yahata, I. Progogine, J. K. Platten, J. K. Platten, J. K. Platten, K. Lerman, M. A. Dominguez-Lerma, M. Bestehorn, M. Bestehorn, M. C. Cross, M. C. Cross, M. C. Cross, M. C. Cross, M. Liu, M. Lücke, N. D. Stein, O. Lhost, O. Lhost, P. Büchel, P. Glandsdorff, P. Huerre, P. Huerre, P. Kolodner, P. Kolodner, P. Le Gal, R. J. Briggs, R. J. Deissler, R. P. Behringer, S. Chandrasekhar, S. J. Linz, St. Hollinger, T. Clune, V. Croquette, V. Croquette, V. Steinberg, W. Barten, W. Barten, W. Hort, W. Schöpf, W. Schöpf   +62 more
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Quantum Limitations on the Storage and Transmission of Information

, 2003
Information must take up space, must weigh, and its flux must be limited. Quantum limits on communication and information storage leading to these conclusions are here described. Quantum channel capacity theory is reviewed for both steady state and burst
Bekenstein, Jacob D., Schiffer, Marcelo
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Coexistence of pairing gaps in three-component Fermi gases

, 2011
We study a three-component superfluid Fermi gas in a spherically symmetric harmonic trap using the Bogoliubov-deGennes method. We predict a coexistence phase in which two pairing field order parameters are simultaneously nonzero, in stark contrast to ...
J J Kinnunen, Larkin A I, Luscher A Laeuchli A, Modawi A G W, O H T Nummi, P Törmä   +5 more
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Unitary and non-unitary transitions around a cosmological bounce

, 2014
In this work, we investigate the notion of time and unitarity in the vicinity of a bounce in quantum cosmology, that is, a turning point for the scale factor.
Coutant, Antonin
core   +2 more sources