Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
An outer approximation method for the road network design problem. [PDF]
PLoS One, 2018 Asadi Bagloee S, Sarvi M.
europepmc +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
A discrete approximation method for modeling interval-censored multistate data. [PDF]
Stat MedYou L, Liu X, Krischer J.
europepmc +1 more source
Multi-sector approximation method for arteries: the residual stresses of circumferential rings with non-trivial openings. [PDF]
J R Soc Interface, 2019 Sigaeva T, Destrade M, Di Martino ES.
europepmc +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
On Filtering in Markovian Term Structure Models (An Approximation Approach) [PDF]
We study a nonlinear filtering problem to estimate, on the basis of noisy observations of forward rates, the market price of interest rate risk as well as the parameters in a particular term structure model within the Heath-Jarrow-Morton family.
Sara Pasquali +2 more
core
Accurate EVSI Estimation for Nonlinear Models Using the Gaussian Approximation Method. [PDF]
Med Decis MakingLi L, Jalal H, Heath A.
europepmc +1 more source
Smoothing sample average approximation method for solving stochastic second-order-cone complementarity problems. [PDF]
J Inequal Appl, 2018 Luo M, Zhang Y.
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Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source