Results 71 to 80 of about 11,744,309 (247)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

SWTA-Shapley: an efficient contribution evaluation method for federated learning

open access: yesDianxin kexue
Federated learning has effectively addressed the “data silo” issue caused by data privacy protection. To maintain the long-term operation of federated learning systems, it is necessary to attract high-quality data owners to participate in federated ...
BAO Shihao, NI Zhengwei
doaj   +2 more sources

A Neural Network Approximation Based on a Parametric Sigmoidal Function

open access: yesMathematics, 2019
It is well known that feed-forward neural networks can be used for approximation to functions based on an appropriate activation function. In this paper, employing a new sigmoidal function with a parameter for an activation function, we consider a ...
Beong In Yun
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

A comparison between the improved element-free Galerkin method and the element-free Galerkin method for 2D potential and elasticity problems

open access: yesComputer Assisted Methods in Engineering and Science, 2017
In this paper, a comparison between the improved element-free Galerkin (IEFG) method, based on the improved moving least square (IMLS) approximation, and the element-free Galerkin (EFG) method, based on the moving least square (MLS) approximation, is ...
Imen Debbabi   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Approximation of 2π-periodic functions by Taylor—Abel—Poisson operators in the integral metric

open access: yesДоповiдi Нацiональної академiї наук України
We obtain direct and inverse approximation theorems of 2π-periodic functions by Taylor — Abel — Poisson operators in the integral metric.
J. Prestin, V.V. Savchuk, A.L. Shidlich
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

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