Results 61 to 70 of about 19,468 (288)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Uncertainty quantification and weak approximation of an elliptic inverse problem [PDF]

open access: yes, 2011
We consider the inverse problem of determining the permeability from the pressure in a Darcy model of flow in a porous medium. Mathematically the problem is to find the diffusion coefficient for a linear uniformly elliptic partial differential equation ...
Worthington, Claire   +14 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Approximation by Rational Functions in Variable Exponent Morrey–Smirnov Classes

open access: yesJournal of Mathematics, 2022
In this work, the direct theorem of approximation theory in variable exponent Morrey–Smirnov classes of analytic functions, defined on a doubly connected domain of the complex plane bounded by two sufficiently smooth curves, is investigated.
Ahmed Kinj
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Analysis of Higher-Order Bézier Curves for Approximation of the Static Magnetic Properties of NO Electrical Steels

open access: yesMathematics
Adequate mathematical description of magnetization curves is indispensable in engineering. The accuracy of the description has a significant impact on the design of electric machines and devices.
Ermin Rahmanović, Martin Petrun
doaj   +1 more source

Approximation of Analytic Functions by Universal Vallee-Poussin Sums on the Chebyshev Polynomials

open access: yesИзвестия Иркутского государственного университета: Серия "Математика", 2018
As it is known, Chebyshev polynomials provide the best uniform approach of a function. They are a special case of Faber polynomials. A. I. Shvay (1973) proved that the Vallee-Poussin sums are the best approach apparatus in comparison with the partial ...
L.K. Dodunova, A.A. Ageikin
doaj   +1 more source

The numerical approximation of analytic functions in the complex domain

open access: yes, 1980
In this paper we are concerned with the numerical approximation of analytic functions in the complex domain. This approach leads to an efficient technique for deriving an interpolation polynomial as well as a useful error ...
Price, Thomas E.
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

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