Results 101 to 110 of about 887,414 (331)

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

open access: yesMolecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva   +5 more
wiley   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

open access: yesMolecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima   +6 more
wiley   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

open access: yesMolecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li   +12 more
wiley   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

open access: yesMolecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi   +12 more
wiley   +1 more source

Approximation properties of Jacobi's algorithm

open access: yesMonatshefte f�r Mathematik, 1976
The paper improves a previous result which is a generalization of Hurwitz' theorem for Jacobi's algorithm.
openaire   +3 more sources

Approximation Properties for Discrete Groups [PDF]

open access: yes, 2006
We provide an illustration of an interesting and nontrivial interaction between analytic and geometric properties of a group. We provide a short survey of approximation properties of operator algebras associated with discrete groups. We then demonstrate directly that groups that satisfy the property RD with respect to a conditionally negative length ...
Brodzki, Jacek, Niblo, Graham A.
openaire   +2 more sources

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

open access: yesMolecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza   +5 more
wiley   +1 more source

On How QCD Gauge Invariance Gets Realized in the Context of Effective Locality

open access: yesAdvances in High Energy Physics, 2018
The fermionic Green’s functions of QCD exhibit an unexpected property of effective locality, which appears to be exact, involving no approximation. This property is nonperturbative, resulting from a full integration of the elementary gluonic degrees of ...
H. M. Fried, T. Grandou, R. Hofmann
doaj   +1 more source

Runge approximation on convex sets implies the Oka property

open access: yes, 2005
We prove that the classical Oka property of a complex manifold Y, concerning the existence and homotopy classification of holomorphic mappings from Stein manifolds to Y, is equivalent to a Runge approximation property for holomorphic maps from compact ...
Forstneric, Franc
core  

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