Results 161 to 170 of about 9,794,717 (361)

Identification of amino acids essential for angulin‐1/3 binding of the tricellular tight junction binder, angubindin‐1

open access: yesFEBS Open Bio, EarlyView.
Angubindin‐1 binds angulin‐1/‐3 at tricellular tight junctions, enhancing intestinal macromolecule permeation. Alanine scanning identified six essential residues (L562, L598, E638, V640, Y643, and K644) of angubindin‐1 critical for binding to angulin‐1/‐3 and permeation‐enhancing activity, providing insights for the development of targeted noninvasive ...
Taiki Kuzu   +8 more
wiley   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

open access: yesFEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti   +8 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

The Depth Distribution Law of the Polarization of the Vector Acoustic Field in the Ocean Waveguide

open access: yesJournal of Marine Science and Engineering
The polarization of the acoustic field in the ocean waveguide environment is a unique property that can provide new ideas for locating and detecting the underwater target, so it is interesting to study the polarization.
Yizheng Wei, Chao Sun
doaj   +1 more source

Approximate extension property of mappings

open access: yesTopology and its Applications, 2012
AbstractThe extension problem is to determine the extendability of a mapping defined on a closed subset of a space into a nice space such as a CW complex over the whole space. In this paper, we consider the extension problem when the codomains are general spaces.
openaire   +2 more sources

Performance of Composite Endpoints Defining Progression Independent of Relapse Activity in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The characteristics and utility of composite progression independent of relapse activity (cPIRA; worsening on the Expanded Disability Status Scale [EDSS], or 9‐Hole Peg Test, or Timed 25‐Foot Walk Test) were evaluated as an endpoint in relapsing multiple sclerosis (RMS) trials using the ENSEMBLE (NCT03085810) and pooled OPERA I/II ...
Ludwig Kappos   +11 more
wiley   +1 more source

On convergence of Chlodovsky type Durrmeyer polynomials in variation seminorm

open access: yesJournal of Numerical Analysis and Approximation Theory, 2018
This paper deals with the variation detracting property and rate of approximation of the Chlodovsky type Durrmeyer polynomials in the space of functions of bounded variation with respect to the variation seminorm.
Özlem Öksüzer Yilik   +2 more
doaj   +2 more sources

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