Results 61 to 70 of about 887,414 (331)
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Korovkin Second Theorem via -Statistical -Summability
Abstract and Applied Analysis, 2013 Korovkin type approximation theorems are useful tools to check whether a given sequence of positive linear operators on of all continuous functions on the real interval is an approximation process.
M. Mursaleen, A. Kiliçman
doaj +1 more source
FEBS Letters, EarlyView.In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker +8 more
wiley +1 more source
On generalized Baskakov-Durrmeyer-Stancu type operators
Demonstratio Mathematica, 2017 In this paper, we study some local approximation properties of generalized Baskakov-Durrmeyer-Stancu operators. First, we establish a recurrence relation for the central moments of these operators, then we obtain a local direct result in terms of the ...
Kumar Angamuthu Sathish +2 more
doaj +1 more source
Development of visible light‐sensitive human neuropsin (OPN5) via single amino acid substitution
FEBS Letters, EarlyView.The present study determines a key amino acid residue, Lys91, for defining UV sensitivity of human OPN5. Heterologous action spectroscopy of the wild type and K91 mutants of OPN5 in HEK293T cells reveals that substitution of Lys91 with neutral (alanine) or acidic amino acids (glutamic or aspartic acids) causes substantial shifts in spectral sensitivity
Yusuke Sakai +2 more
wiley +1 more source
Coarse median structures and homomorphisms from Kazhdan groups
, 2015 We study Bowditch's notion of a coarse median on a metric space and formally introduce the concept of a coarse median structure as an equivalence class of coarse medians up to closeness.
Zeidler, Rudolf
core +1 more source
Properties of an approximate hazard transform
Naval Research Logistics Quarterly, 1975 AbstractThe calculation of the exact reliability of complex systems is a difficult and tedious task. Consequently simple approximating techniques have great practical value.The hazard transform of a system is an invertible transformation of its reliability function which is convenient and useful in both applied and theoretical reliability work.
Esary, J.D., Hayne, W.J.
openaire +4 more sources
The weak metric approximation property [PDF]
Mathematische Annalen, 2005 The authors define the \textit{weak \(\lambda\)-bounded approximation property} (\(\lambda\)-\(wBAP\)) for a Banach space \(X\) in the following way: for every Banach space \(Y\) and every weakly compact operator \(T\colon X \to Y\), there exists a net of finite rank operators \(S_\alpha \colon X \to X\) which converges uniformly on compact subsets of \
Åsvald Lima, Eve Oja
openaire +3 more sources
Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells
FEBS Letters, EarlyView.Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan +2 more
wiley +1 more source
FEBS Letters, EarlyView.Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile +8 more
wiley +1 more source