Results 21 to 30 of about 284 (126)
Prevalence， diagnosis， and treatment progress of resistant hypertension [PDF]
Zhenduanxue lilun yu shijianResistant hypertension (RH), defined as uncontrolled blood pressure despite the use of optimal combination therapy, represents a major clinical treatment challenge.
MA Zhiqiang, LIN Zixin, WU Hao, WANG Zaijia, ZHANG Xiangtao, DONG Yifei
doaj +2 more sources
Aprocitentan for Blood Pressure Reduction in Black Patients
HypertensionBACKGROUND: Black individuals frequently present with resistant hypertension and disproportionately increased cardiovascular risk. We investigated the blood pressure (BP)-lowering effect of the dual endothelin receptor antagonist aprocitentan in Black individuals enrolled in the PRECISION study (Parallel-Group, Phase 3 Study ...
, Markus P Schlaich, Michael A Weber
exaly +3 more sources
A Game Changer for Resistant Hypertension: The Rise of Aprocitentan
Journal of Cardiovascular PharmacologyAbstract: Hypertension is a major risk factor for cardiovascular disease, and a major contributor to global morbidity and mortality. In particular, resistant hypertension (rHTN), defined as blood pressure that remains elevated despite treatment with at least three antihypertensive agents including a diuretic, continues to be a major ...
Eid, Ali H.
openaire +4 more sources
ACS Medicinal Chemistry LettersAprocitentan, a dual endothelin receptor antagonist recently approved for the treatment of resistant hypertension, contains a sulfamide moiety structurally related to known zinc-binding groups found in carbonic anhydrase (CA) inhibitors. Given the central role of CAs in renal and vascular physiology, we investigated whether aprocitentan exerts ...
Andrea Angeli +2 more
exaly +3 more sources
Bioequivalence and the food effect of macitentan/tadalafil 10/20 fixed-dose combination tablets versus the use of single-component tablets in healthy subjects. [PDF]
Pharmacol Res PerspectArithmetic mean plasma concentration versus time profiles for macitentan, aprocitentan and tadalafil during the first 24 hours and 216 hours after administration of Treatment A (FDC, fasted), Treatment B (FDC, fed), and Treatment C (free combination, fasted).
Ford JL +6 more
europepmc +2 more sources
The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
British Journal of Pharmacology, Volume 180, Issue S2, Page S23-S144, October 2023., 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander +165 more
wiley +1 more source
Revisiting resistant hypertension: a comprehensive review
Internal Medicine Journal, Volume 53, Issue 10, Page 1739-1751, October 2023., 2023 Abstract Resistant hypertension (RHT) is typically defined as blood pressure that remains above guideline‐directed targets despite the use of three anti‐hypertensives, usually including a diuretic, at optimal or maximally tolerated doses. It is generally estimated to affect 10–30% of those diagnosed with hypertension, though the true incidence might be
Ryan J. Chan +2 more
wiley +1 more source
Endothelin receptor antagonists in kidney protection for diabetic kidney disease and beyond?
Nephrology, Volume 28, Issue 2, Page 97-108, February 2023., 2023 Abstract The burden of chronic kidney disease is increasing worldwide, largely due to the increasing global prevalence of diabetes mellitus and hypertension. While renin angiotensin system inhibitors and sodium‐glucose cotransporter two inhibitors are the management cornerstone for reducing kidney and cardiovascular complications in patients with ...
Edmund Y. M. Chung +3 more
wiley +1 more source
Hypertension in chronic kidney disease-treatment standard 2023. [PDF]
Nephrol Dial Transplant, 2023 Hypertension is very common and remains often poorly controlled in patients with chronic kidney disease (CKD). Accurate blood pressure (BP) measurement is the essential first step in the diagnosis and management of hypertension.
Georgianos PI, Agarwal R.
europepmc +2 more sources
Pharmacology Research &Perspectives, Volume 9, Issue 5, October 2021., 2021 The macitentan 10 mg/tadalafil 40 mg Fixed Dose Combination is bioequivalent to the free combination. No clinically significant differences in PK were determined between fed and fasted conditions of the FDC formulation. Abstract The COVID‐19 pandemic has forced clinical studies to accommodate imposed limitations.
Dénes Csonka +6 more
wiley +1 more source