Results 141 to 150 of about 87,926 (266)

Compensatory rearrangement of parvalbumin interneuron voltage‐gated sodium channel subunits in a mouse model of Dravet syndrome

Epilepsia, EarlyView.
Abstract Heterozygous loss‐of‐function variants in the gene SCN1A, which encodes the voltage‐gated sodium channel (VGSC) pore‐forming (α) subunit NaV1.1, lead to a spectrum of neurological disease, including Dravet syndrome. NaV1.1 is prominently expressed at the proximal portion of the axon initial segment (AIS) of fast‐spiking γ‐aminobutyric ...
Ania K. Dabrowski, Ala Somarowthu, Sophie R. Liebergall, Damaris N. Lorenzo, Ethan M. Goldberg   +4 more
wiley   +1 more source

Timing is everything: The effect of early‐life seizures on developing neuronal circuits subserving spatial memory

Epilepsia Open, EarlyView.
Abstract Spatial memory, the aspect of memory involving encoding and retrieval of information regarding one's environment and spatial orientation, is a complex biological function incorporating multiple neuronal networks. Hippocampus‐dependent spatial memory is not innate and emerges during development in both humans and rodents.
Gregory L. Holmes
wiley   +1 more source

Validation of a handheld smartphone markerless gait‐analysis tool using an estimated groundline in horses

Equine Veterinary Journal, EarlyView.
Abstract Background A handheld smartphone‐based computer vision algorithm (RealHorse® [RH]) offers accessible alternatives for equine gait analysis but requires validation against a gold‐standard three‐dimensional multicamera optical motion capture system (Qualisys® [QS]).
Karsten Key, Jakob Kirkegaard, Katja Berg, Kristian Ringkjær Andresen, Sabrina Skov Hansen   +4 more
wiley   +1 more source

Multi‐synergistic strategy for dual‐sensing conductive hydrogels capable of simultaneous strain and temperature monitoring

FlexMat, EarlyView.
In this study, a multicomponent synergistic strategy is utilized, which capitalizes on the “intersection” of multiple functional influencing factors to achieve the successful development of a multifunctional hydrogel. Through the construction of a unique three‐dimensional dynamic cross‐linked network, the material combines mechanical strength ...
Wei Li, Weidong Xu, Libing Yang, Wanyang Lin, Yu Chen, Lefei Li, Sitong Chen, Chan Zheng, Jianying Huang, Weilong Cai, Yuekun Lai   +10 more
wiley   +1 more source

Research progress on flexible MXene‐based materials in advanced energy storage devices: From preparation strategies to device applications

FlexMat, EarlyView.
This review summarizes MXene synthesis and flexible electrode fabrication for FESDs, highlighting their potential owing to high conductivity and flexibility, and outlines future research directions. Abstract The rapid development of wearable and portable electronics has created demand for flexible energy storage systems (FESDs) that not only exhibit ...
Nanxi Miao, Ying Lu, Xing Gao, Lingzi Pan, Meng Gao, Chenxi Zhang, Ming Liu, Shizhong Wang, Zhongyu Weng, Huan Pang, Huijie Zhou   +10 more
wiley   +1 more source

Measurement properties of the USER-Participation Restriction subscale and PROMIS^® Ability to Participate in Social roles and Activities in in- and outpatient rehabilitation populations. [PDF]

Qual Life Res
Mourits BMP, Scholten EWM, de Graaf JA, Smeets RJEM, Nachtegaal J, de Boer CE, van Nes IJW, Reneman MF, Oosterveer DM, Valk-Kleibeuker L, Agterhof EWJ, Roorda LD, Visser-Meily JMA, Post MWM.   +13 more
europepmc   +1 more source

Almond (Amygdalus communis L.) Peptides Improve Scopolamine‐Induced Learning and Memory Impairment in Mice

Food Safety and Health, EarlyView.
Figure Schematic showing the improvement of almond peptides on learning and memory impairment induced by scopolamine in mice. Almond peptides (APs) could improve the learning and memory in scopolamine‐induced mice by maintaining cholinergic system homeostasis and regulating Nrf2/Keap1 signaling pathway, via activating the Nrf2 transcription factor and ...
Xin Shang, Wenjing Gao, Caiyun Zhao, Bin Li, Jintian Guo, Jingteng Wang, Minwei Zhang, Yinghua Fu   +7 more
wiley   +1 more source

Long-term follow-up of autoimmune polyendocrine syndrome type 1 in Norway.

J Clin Endocrinol Metab
Kucuka I, Wolff ASB, Breivik L, Sjøgren T, Bratland E, Grytaas M, Lima K, Jørgensen AP, Nermoen I, Bakke Å, Singsås H, Svendsen M, Finnes TE, Nedrebø BG, Haug T, Grimnes G, Rensvik ML, Gjerde CG, Marthinussen MC, Øksnes M, Oftedal BE, Husebye ES.   +21 more
europepmc   +1 more source

Patterns of headache in patients with antiphospholipid syndrome in relation to autoantibodies. [PDF]

J Headache Pain
Soliman R, Mahfouz YG, El-Skaan RGA, Mohamed WAS.   +3 more
europepmc   +1 more source

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source