The Anti-Inflammatory Effect of Aptamin C on House Dust Mite Extract-Induced Inflammation in Keratinocytes via Regulation of IL-22 and GDNF Production [PDF]
Antioxidants, 2021 Atopic dermatitis (AD), a chronic inflammatory skin disease, is characterized by eczemous lesions on the skin that manifest as severe itching and last a long time.
Dahae Lee +9 more
doaj +6 more sources
Anti-Inflammatory Effects of Aptamin C in Pulmonary Fibrosis Induced by Bleomycin [PDF]
PharmaceuticalsBackground/Objectives: Vitamin C is a well-known antioxidant with antiviral, anticancer, and anti-inflammatory properties. However, its therapeutic applications are limited by rapid oxidation due to heat and light sensitivity.
Seulgi Shin +9 more
doaj +5 more sources
Effect of Aptamin C on NK Cell Activity and Cytotoxicity: A Randomized Placebo-Controlled Trial and In Vitro Comparison with Vitamin C [PDF]
AntioxidantsNatural killer (NK) cells are crucial components of innate immunity and rapidly eliminate abnormal cells through ligand–receptor signaling without prior sensitization.
Hyovin Ahn +5 more
doaj +4 more sources
Advances in dermatology using DNA aptamer "Aptamin C" innovation: Oxidative stress prevention and effect maximization of vitamin C through antioxidation. [PDF]
J Cosmet Dermatol, 2020 AbstractBackgroundVitamin C (also known as L‐ascorbic acid) plays a critical role in reactive oxygen species (ROS) reduction and cell regeneration by protecting cell from oxidative stress. Although vitamin C is widely used in cosmetic and therapeutic markets, there is considerable evidence that vitamin C easily undergoes oxidation by air, pH ...
Choi S +8 more
europepmc +5 more sources
NXP032 Ameliorates Aging-Induced Oxidative Stress and Cognitive Impairment in Mice through Activation of Nrf2 Signaling [PDF]
Antioxidants, 2022 Aging is a neurodegenerative disease that leads to cognitive impairment, and an increase in oxidative stress as a major cause is an important factor.
Jae-Min Lee +3 more
doaj +2 more sources
NXP031 prevents dopaminergic neuronal loss and oxidative damage in the AAV-WT-α-synuclein mouse model of Parkinson's disease. [PDF]
PLoS ONE, 2022 Parkinson's disease (PD) is a neurodegenerative disease characterized by inclusions of aggregated α-synuclein (α-Syn). Oxidative stress plays a critical role in nigrostriatal degeneration and is responsible for α-Syn aggregation in PD.
Min Kyung Song +3 more
doaj +2 more sources
Aptamin C enhances anti-cancer activity NK cells through the activation of STAT3: a comparative study with vitamin C. [PDF]
Anat Cell BiolVitamin C is a well-known antioxidant with antiviral, anticancer, and anti-inflammatory properties based on its antioxidative function. Aptamin C, a complex of vitamin C with its specific aptamer, has been reported to maintain or even enhance the efficacy of vitamin C while increasing its stability.
Agura T +9 more
europepmc +3 more sources
NK cells are crucial for innate immunity and rapidly target abnormal cells through ligand-receptor signaling, without prior sensitization. Vitamin C is a bioenhancer of NK cells; however, its susceptibility to oxidation limits its efficacy in NK cell activation.
Hyovin Ahn +5 more
openaire +2 more sources
NXP081, DNA Aptamer-Vitamin C Complex Ameliorates DNFB-Induced Atopic Dermatitis in Balb/c Mice. [PDF]
Nutrients, 2023 Lee S +6 more
europepmc +1 more source
NXP032 ameliorates cognitive impairment by alleviating the neurovascular aging process in aged mouse brain. [PDF]
Sci Rep, 2023 Lee JM, Lee JH, Kim SH, Sim TH, Kim YJ.
europepmc +1 more source