Results 101 to 110 of about 22,200,369 (327)

Amelioration of Post‐Stroke Edema and Microcirculatory Dysfunction via Targeted AQP4 Inhibition While Preserving the Glymphatic System

Advanced Science, EarlyView.
Compared to untargeted therapy, the targeted nanocarrier, Angiopep‐2‐conjugated Lipid Nanoparticle (A‐LNP) loaded with TGN‐020 (TGN), selectively accumulated in stroke‐injured regions. It suppressed local aquaporin‐4 (AQP4) overexpression, thereby alleviating cerebral edema and hypoperfusion while preserving global glymphatic clearance.
Lei Jin, Zeyu Yang, Boyang Wei, Yu Wu, Longxiang Li, Jiaming Zhou, Xin Zhang, Fa Jin, Shixing Su, Yanchao Liu, Ran Li, Shenquan Guo, Xingwu Liu, Yu Cai, Hong Liu, Min Chen, Wenchao Liu, Chuanzhi Duan, Xifeng Li   +18 more
wiley   +1 more source

Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases: Molecular Mechanism of Water Channel Aquaporin-2 Trafficking

Journal of Pharmacological Sciences, 2004
Targeted positioning of water channel aquaporin-2 (AQP2) strictly regulates body water homeostasis. Trafficking of AQP2 to the apical membrane is critical for the reabsorption of water in renal collecting ducts.
Yumi Noda, Sei Sasaki
doaj   +1 more source

Endogenous bioelectric currents promote differentiation of the mammalian lens [PDF]

, 2018
Acknowledgements We are grateful to Kevin S. Mackenzie in our imaging core facility. This work was supported by the University of Aberdeen (at which the majority of the experimental work was conducted).
Andley, Banno, Barrett, Bassnett, Bhat, Bhuyan, Blackiston, Bortner, Call, Cao, Chen, Chen, Chen, Eperon, Franco, Gwon, Gwon, Ibaraki, Kalous, Kolosova, Korlimbinis, Lampi, Lampi, Lee, Liu, Lois, Lovicu, Mathias, McCaig, Park, Patterson, Piatigorsky, Rajagopal, Robinson, Robinson, Sanderson, Sellitto, Shestopalov, Shestopalov, Sundelacruz, Sundelacruz, Sundelacruz, Thylefors, Ueda, Vaghefi, Wang, Wang, Wang, White, Wind, Wormstone, Yang, Zhao   +52 more
core   +1 more source

Autophagic degradation of aquaporin-2 is an early event in hypokalemia-induced nephrogenic diabetes insipidus

Scientific Reports, 2015
Hypokalemia (low serum potassium level) is a common electrolyte imbalance that can cause a defect in urinary concentrating ability, i.e., nephrogenic diabetes insipidus (NDI), but the molecular mechanism is unknown.
S. Khositseth, P. Uawithya, P. Somparn, Komgrid Charngkaew, Nattakan Thippamom, J. Hoffert, F. Saeed, D. Payne, Shu-Hui Chen, R. Fenton, T. Pisitkun, T. Pisitkun   +11 more
semanticscholar   +1 more source

Myelitis‐Predominant Aggressive Phenotype: Unveiling Unique Patterns of Late‐Onset Neuromyelitis Optica Spectrum Disorders

Annals of Neurology, EarlyView.
Objective The objective of this study was to compare clinical features and prognosis of late‐onset neuromyelitis optica spectrum disorder (LO‐NMOSD, onset age ≥60 years) with adult‐onset NMOSD (AO‐NMOSD, onset age 18–59 years), and to provide insights for individualized management in elderly patients.
Ya‐Lan Pu, Jin‐Zhou Feng, Hua‐Xing Meng, Hai‐Bing Xiao, Xiao‐Ling Li, Jin Zhen, Wen‐Ying Lu, Xu‐Ming Xi, Ti Wu, Bao‐Shi Yuan, Mo‐Li Fan, Chao Zhang, De‐Cai Tian, Xia Meng, Fu‐Dong Shi, Tian Song   +15 more
wiley   +1 more source

Gi Protein Modulation of the Potassium Channel TASK-2 Mediates Vesicle Osmotic Swelling to Facilitate the Fusion of Aquaporin-2 Water Channel Containing Vesicles

Cells, 2018
Vesicle fusion is a fundamental cell biological process similar from yeasts to humans. For secretory vesicles, swelling is considered a step required for the expulsion of intravesicular content.
Mariangela Centrone, Maria Penelope De Santo, Isabella Nicotera, Cristina Labate, Marianna Ranieri, Annarita Di Mise, Maria Grazia Mola, Maria Mastrodonato, Rosangela Elliani, Riccardo Barberi, Vincenzo Formoso, Grazia Tamma, Giovanna Valenti   +12 more
doaj   +1 more source

Marked central nervous system pathology in CD59 knockout rats following passive transfer of Neuromyelitis optica immunoglobulin G. [PDF]

, 2017
Neuromyelitis optica spectrum disorders (herein called NMO) is an inflammatory demyelinating disease of the central nervous system in which pathogenesis involves complement-dependent cytotoxicity (CDC) produced by immunoglobulin G autoantibodies ...
Verkman, Alan S, Yao, Xiaoming
core   +2 more sources

Aquaporin-2 water channels in spontaneously hypertensive rats [PDF]

American Journal of Hypertension, 2004
Vasopressin (AVP), an antidiuretic hormone, is known to induce hypervolemia and to regulate the renal expression of aquaporin-2 (AQP2) water channels, but it is not yet known whether the latter are involved in the pathogenesis of essential hypertension.
BUEMI, Michele, NOSTRO L, DI PASQUALE, Giuseppe, CAVALLARO, EMANUELA, STURIALE, ALESSIO, FLOCCARI F, ALOISI, Carmela, RUELLO A, CALAPAI, Gioacchino, CORICA, Francesco, FRISINA, Nicola   +10 more
openaire   +2 more sources

Comprehending the Membrane Properties for Emulation in Organs‐on‐a‐Chip

Advanced NanoBiomed Research, EarlyView.
The advent of organ‐on‐chip models allows closer emulation of in vivo conditions, leading to effective, less costly, and specific drugs. Although a number of membrane‐based on‐chip models exist, better emulating functional models need to be devised for organ simulations.
Tanmayee Makarand Sathe, Dhananjay Shrikrishna Bodas   +1 more
wiley   +1 more source

In silico analysis of molecular mimicry between human aquaporin 3, Aspergillus fumigatus aquaporin and aquaporins from allergic sources [version 2; peer review: 2 approved]

F1000Research
Background Atopic dermatitis (AD) is a chronic inflammatory skin condition that has a significant impact on quality of life. The immune response and allergy symptoms in AD are triggered by the recognition of specific allergens by IgE antibodies.
Andrés Sánchez, Juan Urrego, Claudia Baena, Carlos Bernal, Adriana Lorduy, Jorge Sanchez, Marlon Munera, Yaquelin Padilla   +7 more
doaj   +1 more source