Results 41 to 50 of about 36,467 (231)

Extracellular Matrix Viscoelasticity Regulates Mammary Branching Morphogenesis

Advanced Science, EarlyView.
This study shows that mammary branching morphogenesis is regulated by extracellular matrix (ECM) stress relaxation. Slow stress‐relaxing matrices promote branching through focal adhesion signaling, collagen fiber alignment, and cell contractions, whereas fast stress‐relaxing matrices impair branching and collagen alignment.
Daniella I. Walter, Juliette W. Moore, Abhishek Sharma, Ryan S. Stowers   +3 more
wiley   +1 more source

Hormonal regulation of ovarian bursa fluid in mice and involvement of aquaporins. [PDF]

PLoS ONE, 2013
In rodent species, the ovary and the end of oviduct are encapsulated by a thin membrane called ovarian bursa. The biological functions of ovarian bursa remain unexplored despite its structural arrangement in facilitating oocytes transport into oviduct ...
He Zhang, Ying Zhang, Huashan Zhao, Yunfang Zhang, Qi Chen, Hongying Peng, Li Lei, Jingqiao Qiao, Junchao Shi, Zhonghong Cao, Enkui Duan, Yaping Jin   +11 more
doaj   +1 more source

GSK3β‐Regulated Lipolysis is Required for Histone Acetylation and Decidualization in Early Pregnancy

Advanced Science, EarlyView.
Uterine Gsk3b knockout impairs decidual cell terminal differentiation by causing lipid droplet accumulation. GSK3β phosphorylates RNF213 to promote its lysosomal degradation, thereby enhancing lipolysis. The released fatty acids undergo β‐oxidation to generate acetyl‐CoA, which modulates histone acetylation and regulates decidual cell terminal ...
Peiran Wang, Yedong Tang, Xueling Zhao, Yu Ni, Hualan Zhou, Enhao Zhang, Gaizhen Li, Han Cai, Yinan Wang, James R. Woodgett, Wenbo Deng, Haibin Wang, Zhongxian Lu, Haili Bao, Shuangbo Kong   +14 more
wiley   +1 more source

Deficiency of Carbonic Anhydrase II Results in a Urinary Concentrating Defect

Frontiers in Physiology, 2018
Carbonic anhydrase II (CAII) is expressed along the nephron where it interacts with a number of transport proteins augmenting their activity. Aquaporin-1 (AQP1) interacts with CAII to increase water flux through the water channel. Both CAII and aquaporin-
Devishree Krishnan, Devishree Krishnan, Wanling Pan, Megan R. Beggs, Megan R. Beggs, Francesco Trepiccione, Régine Chambrey, Régine Chambrey, Dominique Eladari, Dominique Eladari, Emmanuelle Cordat, Emmanuelle Cordat, Henrik Dimke, R. Todd Alexander, R. Todd Alexander, R. Todd Alexander   +15 more
doaj   +1 more source

Comprehensive study of Algerian nettles: Phenolic content and multifunctional activities of Urtica pilulifera and Urtica urens

Animal Models and Experimental Medicine, EarlyView.
This study investigates the phenolic profile, antioxidant capacity, antimicrobial effect, and antihemolytic activity of nettle leaves from Algerian species Urtica pilulifera and Urtica urens. Results show high levels of flavonoids, tannins, alkaloids, and terpenoids in the extracts.
Hasna Bouhenni, Koula Doukani, Bojana Danilović, Jelena Zvezdanović, Dragan Cvetković, Fahadul Islam, Sherouk Hussein Sweilam, Gehan Ahmed Othman, Talha Bin Emran   +8 more
wiley   +1 more source

Nanobiotechnology‐Based Approaches for Targeted Glioma Therapy

Advanced NanoBiomed Research, EarlyView.
Nanoparticle systems cross the blood–brain barrier to deliver drugs precisely to glioma cells. Lipid, polymeric, and magnetic carriers enable controlled release, tumor targeting, and microenvironment modulation. These nanoplatforms enhance chemotherapy, radiotherapy, and immunotherapy, improving therapeutic efficacy while reducing systemic toxicity ...
Jinwei Li, Yibo He, Yang Zhang, Lining Arnold Ju, Yao Wang, Jianxuan Zhou, Yinying Chai, Xuhui Hui, ShiYuan Tong, Si Zhang, Yanli Tan, Yinyan Wang   +11 more
wiley   +1 more source

Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases: Molecular Mechanism of Water Channel Aquaporin-2 Trafficking

Journal of Pharmacological Sciences, 2004
Targeted positioning of water channel aquaporin-2 (AQP2) strictly regulates body water homeostasis. Trafficking of AQP2 to the apical membrane is critical for the reabsorption of water in renal collecting ducts.
Yumi Noda, Sei Sasaki
doaj   +1 more source

3D‐Printed Microfluidic Bioreactor Incorporating Electrospun Scaffolds for Creating an Enhanced Kidney Epithelial Cell Microenvironment

Journal of Applied Polymer Science, EarlyView.
Overview of cell seeding, attachment and scaffold insertion into bioreactor, with potential analyses listed after conditioning period. ABSTRACT Chronic kidney disease stands as a significant global health challenge, exacerbated by an ongoing scarcity of available organs for transplantation.
Todd P. Burton, Andrew P. Johnston, Alison McDonald, Rhiannon Grant, Anthony Callanan   +4 more
wiley   +1 more source

Integrating Astrocytes in the Sleep–Wake Cycle: The Time Is Now

BioEssays, EarlyView.
Astrocytes actively regulate sleep homeostatic and circadian rheostatic processes, underpinning the sleep–wake cycle. By acting as context‐dependent integrators of internal state and rhythmic environmental inputs, they modulate the encoding properties of neuronal circuitries and contribute to salient temporal representations in the brain.
Marco Brancaccio
wiley   +1 more source

Visual Analytics for Robust Investigations of Placental Aquaporin Gene Expression in Response to Maternal SARS-CoV-2 Infection

Analytics
The human placenta is a multifunctional, disc-shaped temporary fetal organ that develops in the uterus during pregnancy, connecting the mother and the fetus.
Raphael D. Isokpehi, Amos O. Abioye, Rickeisha S. Hamilton, Jasmin C. Fryer, Antoinesha L. Hollman, Antoinette M. Destefano, Kehinde B. Ezekiel, Tyrese L. Taylor, Shawna F. Brooks, Matilda O. Johnson, Olubukola Smile, Shirma Ramroop-Butts, Angela U. Makolo, Albert G. Hayward   +13 more
doaj   +1 more source