Results 181 to 190 of about 334,206 (253)

Substrate‐Selective Inhibition of the SARS‐CoV‐2 Papain‐Like Protease: Inhibition of Hydrolysis of Human Over Viral Substrates

Chemistry – A European Journal, EarlyView.
The SARS‐CoV‐2 papain‐like protease (PLpro) is a medicinal chemistry target. Here we report mass spectrometry assays employing oligopeptide substrates based on the sequences of the viral polyproteins 1a/1ab and on an ISG15‐modified human protein, which enabled the identification of substrate‐selective PLpro inhibitors.
Sakshi Sharma, Peter A. C. Wing, Wojtek Treyde, Shyam Basak, Simeon D. Draganov, Taylah Andrews‐Clark, Eidarus Salah, Petra Lukacik, Claire Strain‐Damerell, Adán Pinto‐Fernández, Martin A. Walsh, Fernanda Duarte, Christopher J. Schofield, Lennart Brewitz   +13 more
wiley   +1 more source

Successful Balloon Valvuloplasty for Paravalvular Leak 4 Months After TAVR in a Bicuspid Aortic Valve. [PDF]

JACC Case Rep
Mosaad M, Algazlan S, Alshamardl K, Alsalman A, Omer H, Elneama A, Alghamedi M, Algathami A.   +7 more
europepmc   +1 more source

Data‐driven simulation of crude distillation using Aspen HYSYS and comparative machine learning models

The Canadian Journal of Chemical Engineering, EarlyView.
Integrated Aspen HYSYS–machine learning framework for predicting product yields and quality variables. Abstract Crude oil refining is a complex process requiring precise modelling to optimize yield, quality, and efficiency. This study integrates Aspen HYSYS® simulations with machine learning techniques to develop predictive models for key refinery ...
Aldimiro Paixão Domingos, Heleno Bispo, Thiago Vaz da Costa, Sérgio Mauro da Silva Neiro   +3 more
wiley   +1 more source

Impact of lean six sigma methodology on healthcare quality in Saudi Arabia: A systematic review. [PDF]

J Educ Health Promot
Sayed SH, Alharbi ZSM, Almuari MS, Aleisawi NA.   +3 more
europepmc   +1 more source

Exploring the Interrelationships Among Supply Chain Emissions, Financial Performance, Market Value, and Board Sustainability: An Exploration of the European Landscape

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT National and supranational institutions are establishing emission trading systems and control schemes in an attempt to manage stakeholders' willingness to engage with regulatory systems and reduce greenhouse gas emissions (GHG). Nonetheless, despite the national and supranational focus on carbon neutrality, little research has been centered ...
Daniele Giordino, Martina Panero, Nourah O. Alshaghdali, Judith Petra Koltai   +3 more
wiley   +1 more source

Multiple breast tumors coexisting with chronic lymphocytic leukemia/small lymphocytic lymphoma: a rare case report. [PDF]

J Surg Case Rep
Allinjawi O, Sait S, Khan S, Fuadah S, Ajabnoor R, Shakra RA, Trabulsi N.   +6 more
europepmc   +1 more source

A Study of High‐Emission Industries: How Policy, Strategy, and Technology Shape Corporate Social Responsibility Toward Carbon Neutrality

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT The extant carbon neutrality (CN) literature largely offers macro‐ or meso‐level analyses, providing limited insights into implementation experiences that could inform granular policymaking and industry strategies. To address this gap, we examine the lived CN experiences of firms in the transportation, energy, manufacturing, and construction ...
Adeel Luqman, Shalini Talwar, Hawazen Almugren, Attila Kurucz, Enrico Battisti   +4 more
wiley   +1 more source

Opioid-related emergency department visits in Saudi Arabia: an interrupted time series analysis of visit patterns pre-COVID-19 and post-COVID-19. [PDF]

BMJ Public Health
Alroba R, Alfakhri A, Aldoughaim M, Aldamiri K, Alrogi N, Alboug K, Gado A, Althunian T, Almadani O.   +8 more
europepmc   +1 more source

Sensemaking and CSR Character in Multinational Corporations: A Comparative Study of Headquarters and Subsidiary Practices in the UAE

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT While corporate social responsibility (CSR) scholarship assumes that organizational consistency signals effectiveness, there remains a knowledge gap about how MNCs navigate competing institutional logics between headquarters and subsidiaries. This study investigates how managerial sensemaking mediates the effects of institutional pressures on ...
Charles Antony Diab, Wendy Stubbs
wiley   +1 more source

Colorectal cancer incidence in Saudi Arabia, 2002-2023: Age-specific trends and implications for screening and prevention. [PDF]

Prev Med Rep
Alshamsan B.
europepmc   +1 more source