Results 171 to 180 of about 474 (238)

The Global Parkinson's Disease Genetics (GP2) Genome Browser

Movement Disorders, EarlyView.
Abstract Background Large‐scale sequencing initiatives have generated extensive genomic resources essential for variant interpretation, yet their effective use often requires bioinformatics expertise. To support identification of Parkinson's disease (PD) risk and disease‐causing variants, we developed an open‐access, summary‐level genomic data browser.
Zih‐Hua Fang, Riley H. Grant, Dan Vitale, Carlos F. Hernandez, Samantha Hong, Hampton L. Leonard, Mary B. Makarious, Lara M. Lange, Matthew Solomonson, Peter Heutink, Allison A. Dilliott, Kamalini Ghosh Galvelis, Mike A. Nalls, Andrew B. Singleton, Cornelis Blauwendraat, the Global Parkinson's Genetics Program (GP2)   +15 more
wiley   +1 more source

Challenges of Pain in Parkinson's Disease: Results from the OCEAN Study

Movement Disorders, EarlyView.
Abstract Background Pain is a common non‐motor symptom in Parkinson’s disease (PD) and is often associated to fluctuations. Objective The OpiCapone Effect on motor fluctuations and pAiN (OCEAN) study evaluated the effect of opicapone on fluctuation‐related pain when added to levodopa therapy in PD patients.
Kallol Ray Chaudhuri, Joaquim J. Ferreira, Angelo Antonini, Olivier Rascol, Monica M. Kurtis, Alexander Storch, José‐Francisco Rocha, Raquel Costa, Diogo Magalhães, Guillermo Castilla‐Fernández, Helena C. Brigas, Joerg Holenz, Per Odin, on behalf of the OCEAN study group   +13 more
wiley   +1 more source

Gene Therapy for Amino Acid Decarboxylase Deficiency: Clinical and Imaging Outcomes in a French Cohort

Movement Disorders, EarlyView.
Abstract Background Intracerebral gene therapy is effective for amino acid decarboxylase (AADC) deficiency, but relationships between anatomical putaminal coverage, metabolic dynamics, and clinical recovery remain poorly understood. Objectives Assess safety, long‐term efficacy, and clinical–radiological correlations in a genetically diverse European ...
Clément Dunoyer, Gaëtan Poulen, Marie‐Céline François‐Heude, Eline Chauvet‐Piat, Bérénice Lecardonnel, Emmanuel Roze, Marie‐Ange Nguyen Morel, Domitille Gras, Adeline Quintard, Gaelle Baroux, Pierre Meyer, Philippe Coubes, Christophe Milesi, Julien Baleine, Chrystelle Sola, Vivien Szabo, Bénédicte Delye, Jana Haberlova, Mohamed Osman Eltahir Babiker, Mohammed Al Muqbil, Stéphanie Sanchez, Souad Touati, Nicolas Leboucq, Virginie Kouyoumdjian, Sylvia Sanquer, Denis Mariano‐Goulart, Thomas Roujeau, Agathe Roubertie   +27 more
wiley   +1 more source

Fault Detection of Electric Motors via Symmetrized Dot Pattern‐Based Features

International Journal of Mechanical System Dynamics, EarlyView.
ABSTRACT This study proposes a novel symmetrized dot pattern (SDP) approach using designed SDP‐based features, extracted from transformed vibration signals, for fault detection. These features describe the compactness, inclination, and shape of the “snowflake” diagram distributions.
Mario Spirto, Pierangelo Malfi, Armando Nicolella, Francesco Melluso, Chiara Cosenza, Sergio Savino, Vincenzo Niola   +6 more
wiley   +1 more source

Optimization of the Cell‐Based Assay Methodology to Study Degradation of Acetylcholine Receptors (Antigenic Modulation) by Antibodies From Myasthenia Gravis Patients

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Degradation of cell‐surface acetylcholine receptors (AChRs) by antigenic modulation is a key pathogenic mechanism of myasthenia gravis (MG) autoantibodies, yet standard assays primarily detect antibody binding rather than functional effects.
Peng Du, Marina Mané‐Damas, Fien M. Verhamme, Mahan Moshir, Peter Ulrichts, Barbie Machiels, Mario Losen, Pilar Martinez‐Martinez   +7 more
wiley   +1 more source

Taxonomic reappraisal of the mangrove genus Avicennia (Acanthaceae) in India

Nordic Journal of Botany, EarlyView.
A taxonomic reappraisal of the mangrove genus Avicennia in India was undertaken through extensive field surveys and critical examination of herbarium specimens. Three taxa, Avicennia alba, Avicennia marina subsp. marina, and Avicennia officinalis, are described in detail. A synonymic list was compiled using the World Checklist of Vascular Plants (WCVP)
Subrata Mondal, Saikat Naskar
wiley   +1 more source

Multi‐year partner fidelity is associated with higher annual reproductive output in a biparental subtropical shorebird

Oikos, EarlyView.
Partner fidelity is a key component of reproductive strategies in socially monogamous species, yet its adaptive value remains context dependent and poorly understood outside environments with short breeding seasons. In most bird species, partners may remain together or re‐pair between successive nesting attempts, but it remains unclear which components
Kateřina Brynychová, Petr Chajma, Lucie Burešová Pešková, Martin Sládeček, Kateřina Trejbalová, Esmat Elhassan, Muna Bilal, Miroslav Šálek   +7 more
wiley   +1 more source

Navigating the Rapids: How Non‐Governmental Organization Managers Develop Strategic Adaptation to Repressive Political Environments

Public Administration and Development, EarlyView.
ABSTRACT This article explores the management adaptation strategies non‐governmental organizations (NGOs) managers employ in order to operate in repressive political environments. It answers the question: how do NGO managers initiate, manage and sustain internal change when the political/regulatory environment changes?
Charles Kaye‐Essien, Shahjahan Bhuiyan, Ghadeer Ali   +2 more
wiley   +1 more source

Why Active Representation Varies: Cultural Stereotypes and Differential Treatment by Street‐Level Bureaucrats

Public Administration and Development, EarlyView.
ABSTRACT How do cultural stereotypes influence the likelihood that minority street‐level bureaucrats (SLBs) will actively represent marginalized subgroups within their ethnocultural community? While existing scholarship on representative bureaucracy has focused on the conditions under which minority SLBs engage in active representation, this study ...
Sohad Amaria, Einat Lavee, Nissim Cohen
wiley   +1 more source

Islamic Public Administration in Practice: The Taliban's “Gender Apartheid” Governance in Afghanistan

Public Administration and Development, EarlyView.
ABSTRACT This article analyzes the Taliban's post‐2021 governance model through the Islamic Public Administration (IPA) framework, focusing on justice, equality, and women's inclusion. It asks: (1) How does the Taliban's governance align with core IPA principles?
Parwiz Mosamim, Jean‐Patrick Villeneuve   +1 more
wiley   +1 more source