Methyl jasmonate and cis jasmone induce apoptosis in Pc-3 and LncaP prostate cancer lines
, 2005 Methyl jasmonate (MJ) and cis jasmone (CJ), lipid-derived plant stress hormones, were studied for their effects against both hormone dependent (LNCaP) and hormone independent (PC3) human prostate cancer cell lines. Both 2 mM MJ or CJ inhibited the growth
Bathina, Madhavi
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Human bronchial fibroblasts express the 5-lipoxygenase pathway [PDF]
, 2006 Background Fibroblasts are implicated in sub-epithelial fibrosis in remodeled asthmatic airways and contribute to airway inflammation by releasing cytokines and other mediators.
Anna J James +4 more
core +2 more sources
Diabetic Cardiovascular Disease Induced by Oxidative Stress. [PDF]
, 2015 Cardiovascular disease (CVD) is the leading cause of morbidity and mortality among patients with diabetes mellitus (DM). DM can lead to multiple cardiovascular complications, including coronary artery disease (CAD), cardiac hypertrophy, and heart failure
Adam, Matti +9 more
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Bone ResearchNociceptive pain is a cardinal feature of traumatic and inflammatory bone diseases. However, whether and how nociceptors actively regulate the immune response during bone regeneration remains unclear.
Xuanyu Qi +7 more
doaj +1 more source
Role of cyclooxygenae-2 and 5-lypoxygenase polymorphisms in Alzheimer's disease in a population from northern Italy:implications for pharmacogenomics [PDF]
, 2010 Alzheimer's disease (AD) is a neurodegenerative disorder clinically characterized by cognitive deficit with progressive worsening of memory. Recent data indicate that neurons, as well as other brain cells, can express enzymes such as cyclooxygenases ...
CANDORE, Giuseppina +6 more
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Arachidonate 5-Lipoxygenase Variants in Atherosclerosis, Obesity, and Bone Traits [PDF]
Circulation Research, 2006 To the Editor: I write regarding publications by Mehrabian et al1,2 appearing in Circulation Research and a subsequent publication by Kuhn et al3 appearing in Arteriosclerosis, Thrombosis, and Vascular Biology . The key implication from the combination of these reports was that amino acid substitutions in arachidonate 5-lipoxygenase (ALOX5) could ...
openaire +1 more source
Multi-walled carbon nanotubes induce arachidonate 5-lipoxygenase expression and enhance the polarization and function of M1 macrophages <i>in vitro</i>. [PDF]
Nanotoxicology, 2023 Lim CS +4 more
europepmc +1 more source
Fatty acids in veterinary medicine and research [PDF]
, 2017 Fatty acid regulation is an essential process for all animals. A number of studies have shown that diet affects the levels/availability of fatty acids in the body but increasingly evidence shows that disease states can alter the amounts within the body ...
Mostyn, Alison +2 more
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Japanese Journal of Pharmacology, 2000 To investigate the cellular sources of arachidonate metabolites during asthma, in vitro productions of thromboxane (TX) B2, prostaglandin (PG) D2, leukotriene (LT) B4 and cysteinyl (Cys) LTs from guinea pig eosinophils and macrophages simultaneously stimulated with the Ca ionophore A23187 were investigated.
T, Nabe, M, Miura, T, Kamiki, S, Kohno
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Relationship between Arachidonate 5-Lipoxygenase-Activating Protein Gene and Peripheral Arterial Disease in Elderly Patients Undergoing General Surgery: A Retrospective Observational Study. [PDF]
Int J Environ Res Public Health, 2023 Jin S +5 more
europepmc +1 more source