Results 111 to 120 of about 16,348 (221)

Modulation of guanosine triphosphatase activity of G proteins by arachidonic acid in rat Leydig cell membranes [PDF]

, 2000
Previous results from our group have indicated that arachidonic acid decrease cAMP production through a modification of heterotrimericGproteins.\ud In the present study, we have characterized the high affinity GTPase activity present in Leydig cell ...
Colás Escudero, Begoña, López Ruiz, María del Pilar, Marinero Ramos, María Jesús, Prieto Villapún, Juan Carlos, Ropero Salinas, Santiago   +4 more
core   +3 more sources

The importance of the lipoxygenase-hepoxilin pathway in the mammalian epidermal barrier [PDF]

, 2014
This review covers the background to discovery of the two key lipoxygenases (LOX) involved in epidermal barrier function, 12R-LOX and eLOX3, and our current views on their functioning.
Brash, Alan R., Keeney, Diane S., Muñoz-Garcia, Agustí, Thomas, Christopher P., Zheng, Yuxiang   +4 more
core   +1 more source

Nonsteroidal Anti-Inflammatory Agents in the Therapy for Experimental Pneumococcal Meningitis [PDF]

, 2017
An increased inflammatory mass in the subarachnoid space during bacterial meningitis may correlate with a poor outcome of disease. Using a rabbit model of pneumococcal meningitis, we sought to reduce this inflammatory process.
Bray, Michael A., Hengstler, Bruno, Rich, Roland, Tomasz, Alexander, Tuomanen, Elaine, Zak, Oto   +5 more
core  

The novel 5-lipoxygenase inhibitor ABT-761 attenuates cerebral vasospasm in a rabbit model of subarachnoid hemorrhage [PDF]

, 2001
OBJECTIVE: Eicosanoids have been implicated in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage (SAH). Leukotrienes, 5-hydroxyperoxyeicosatetraenoic acid, and 5-hydroxyeicosatetraenoic acid are part of this group of substances ...
Arthur, AS, Barbosa, MD, Gazak, C, Kassell, NF, Louis, RH, MacDonald, T, Polin, RS   +6 more
core   +1 more source

Response to Arachidonate 5-Lipoxygenase Variants in Atherosclerosis, Obesity, and Bone Traits [PDF]

Circulation Research, 2006
Since learning of the Letter to the Editor by Lyons1 we sequenced the 5-lipoxygenase (5-LO) gene in strains 129/SvJ, CAST/EiJ, and a congenic strain carrying a CAST/Ei allele. The sequences are in agreement …
openaire   +1 more source

Cross-Linking Mast Cell Specific Gangliosides Stimulates the Release of Newly Formed Lipid Mediators and Newly Synthesized Cytokines

Mediators of Inflammation, 2016
Mast cells are immunoregulatory cells that participate in inflammatory processes. Cross-linking mast cell specific GD1b derived gangliosides by mAbAA4 results in partial activation of mast cells without the release of preformed mediators.
Edismauro Garcia Freitas Filho, Elaine Zayas Marcelino da Silva, Camila Ziliotto Zanotto, Constance Oliver, Maria Célia Jamur   +4 more
doaj   +1 more source

ALOX5 contributes to glioma progression by promoting 5-HETE-mediated immunosuppressive M2 polarization and PD-L1 expression of glioma-associated microglia/macrophages

Journal for ImmunoTherapy of Cancer
Background Oxylipin metabolism plays an essential role in glioma progression and immune modulation in the tumor microenvironment. Lipid metabolic reprogramming has been linked to macrophage remodeling, while the understanding of oxylipins and their ...
Tao Chen, Jiayi Zhou, Jiangang Liu, Jianwei Wang, Zhuohao Liu, Jie Mao, Dinglan Wu, Xiaosheng He, Chenci Wang, Zhengwei Wang, Jiani Lin, Tingzheng Pan, Hongchao Xu   +12 more
doaj   +1 more source

Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma. [PDF]

, 2019
Asthma is a common disorder of the airways characterized by airway inflammation and by decline in lung function and airway remodeling in a subset of asthmatics.
Broide, David H, Hur, Gyu Young
core  

A blockade of leukotriene-mediated Alox5 function provides a new strategy for the treatment of JAK2V617F-induced polycythemia vera

Haematologica
Polycythemia vera (PV) is a hematopoietic stem cell disorder characterized by JAK2V617F, a mutation that gives rise to erythrocytosis. Our previous studies have shown that arachidonate 5-lipoxygenase (Alox5) is a critical driver in PV and the inhibition
Yi Shan, Ngoc DeSouza, Noah Littman, Qiang Qiu, Kathy Nguyen, Yehua Yu, Golam Mohi, Shaoguang Li   +7 more
doaj   +1 more source

HIV X4 Variants Increase Arachidonate 5-Lipoxygenase in the Pulmonary Microenvironment and are associated with Pulmonary Arterial Hypertension. [PDF]

Sci Rep, 2020
Almodovar S, Wade BE, Porter KM, Smith JM, Lopez-Astacio RA, Bijli K, Kang BY, Cribbs SK, Guidot DM, Molehin D, McNair BK, Pumarejo-Gomez L, Perez Hernandez J, Salazar EA, Martinez EG, Huang L, Kessing CF, Suarez-Martinez EB, Pruitt K, Hsue PY, Tyor WR, Flores SC, Sutliff RL.   +22 more
europepmc   +1 more source