Results 171 to 180 of about 16,348 (221)
Tuft cell cysteinyl leukotrienes are necessary for rhinovirus-induced mucus metaplasia, type 2 inflammation and airway hyperresponsiveness in immature mice. [PDF]
Front ImmunolParker DT +11 more
europepmc +1 more source
ALOX15 exerts tumor-suppressive role in head and neck squamous cell carcinoma via ERK pathway. [PDF]
Funct Integr GenomicsLiu A +7 more
europepmc +1 more source
Arachidonate 5-Lipoxygenase Promoter Genotype, Dietary Arachidonic Acid, and Atherosclerosis [PDF]
New England Journal of Medicine, 2004 Leukotrienes are inflammatory mediators generated from arachidonic acid (polyunsaturated n-6 fatty acid) by the enzyme 5-lipoxygenase. Since atherosclerosis involves arterial inflammation, we hypothesized that a polymorphism in the 5-lipoxygenase gene promoter could relate to atherosclerosis in humans and that this effect could interact with the ...
James H Dwyer +2 more
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ALOX5 (arachidonate 5-lipoxygenase) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on ALOX5 (arachidonate 5-lipoxygenase), with data on DNA, on the protein encoded, and where the gene is implicated.
S Banerjee, S Tuncay
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Journal of Lipid Mediators and Cell Signalling, 1995
In this article, it has been attempted to review data primarily on the activation of human 5-lipoxygenase, in vitro and in the cell. First, structural properties and enzyme activities are described. This is followed by the activating factors: Ca2+, membranes, ATP, and lipid hydroperoxide.
Olof Radmark
exaly +4 more sources
In this article, it has been attempted to review data primarily on the activation of human 5-lipoxygenase, in vitro and in the cell. First, structural properties and enzyme activities are described. This is followed by the activating factors: Ca2+, membranes, ATP, and lipid hydroperoxide.
Olof Radmark
exaly +4 more sources
Studies on arachidonate 5-lipoxygenase of rat basophilic leukemia cells
Lipids and Lipid Metabolism, 1984Arachidonate 5-lipoxygenase was partially purified from rat basophilic leukemia cells with the aid of ATP as a ligand linked to Sepharose. The enzyme produced predominantly 5-hydroperoxy-6,8,11,14-eicosatetraenoic acid. Calcium ion was required for the enzyme activity (0.1 mM for half maximal activity), and the calcium-dependent reaction was stimulated
Yamamoto Shozo
exaly +3 more sources
Flavonoids: Potent inhibitors of arachidonate 5-lipoxygenase
Biochemical and Biophysical Research Communications, 1983Various flavonoids were found to be relatively selective inhibitors of arachidonate 5-lipoxygenase which initiates the biosynthesis of leukotrienes with the activity of slow reacting substance of anaphylaxis. Cirsiliol (3',4',5-trihydroxy-6,7-dimethoxyflavone) was most potent, and the enzyme partially purified from rat basophilic leukemia cells was ...
T, Yoshimoto +4 more
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Arachidonate 5-lipoxygenase and its new inhibitors
Journal of Allergy and Clinical Immunology, 1984The 5-lipoxygenases of guinea pig peritoneal polymorphonuclear leukocytes and of rat basophilic leukemia cells have been solubilized, purified partially by affinity chromatography, and shown to convert arachidonic acid principally to 5-hydroperoxy-6,8,11,14- eicosatetraenoic acid.
S, Yamamoto +4 more
openaire +2 more sources
5‐Lipoxygenase‐activating protein stimulates the utilization of arachidonic acid by 5‐lipoxygenase
European Journal of Biochemistry, 19935‐Lipoxygenase (5‐LO) and its activating protein (FLAP) are both required for cellular leukotriene (LT) synthesis, with 5‐LO catalyzing both the synthesis of (5S)‐5‐hydroperoxy 6,8,11,14‐eicosatetraenoic acid (5‐HPETE) from arachidonic acid and the subsequent synthesis of LTA4 from 5‐HPETE. We have previously expressed both human 5‐LO and human FLAP to
M, Abramovitz +5 more
openaire +2 more sources