Results 291 to 300 of about 104,843 (319)
Some of the next articles are maybe not open access.
Renal Arachidonic Acid Metabolism
Annual Review of Physiology, 1984Renal prostaglandin synthesis has been the focus of extensive investigation during the past decade. This chapter reviews the cellular localization of renal arachidonic acid metabolism in view of the substantial recent progress in the isolation and culture of renal cell types.
Mark G. Currie, Philip Needleman
openaire +3 more sources
Arachidonic acid and colorectal carcinogenesis
Molecular and Cellular Biochemistry, 2003Colorectal carcinoma is a leading cause of cancer related death worldwide. This deadly disease advances through a series of clinical and histopathological stages, initiated by single crypt lesions to small benign tumors and finally to malignancy. Although some progress has been made in elucidating the formation of colorectal tumors at molecular/genetic
Siddhartha Das +5 more
openaire +2 more sources
Biological Nitration of Arachidonic Acid
Current Vascular Pharmacology, 2004When a spontaneous autoxidation of arachidonic acid to prostaglandin-like products was first described almost 40 years ago, it was thought to be an artifact that interfered with the detection of enzymatically generated prostaglandins. It has now been generally accepted that the autoxidation of arachidonic acid occurs in vivo and leads to formation of ...
Candace D Poff, Michael Balazy
openaire +3 more sources
Plasma arachidonic acid and the pancreas
Journal of Atherosclerosis Research, 1964Summary This work provides evidence in support of the presence of a factor in the exocrine pancreatic secretion of the dog which regulates the percent composition of plasma arachidonic acid by its action on the cholesterol ester and phospholipid fractions primarily. The factor is distinct from pancreatic enzymes, is heat-stable, and requires adequate
L. Corbo, R. Caren
openaire +3 more sources
Interactions of zinc and arachidonic acid
Prostaglandins and Medicine, 1981To probe the interaction of zinc with polyunsaturated fatty acids we have studied the effect of zinc on the cooxygenation of ferrous iron and arachidonic acid. Zinc inhibited the process of cooxygenation in a concentration dependent fashion. Further evaluation of the interaction of zinc and arachidonic acid gave spectroscopic evidence that zinc, oxygen
J.G. White +4 more
openaire +3 more sources
Preparation of deuterated arachidonic acid
Prostaglandins, 1981Publisher Summary It is reported preparation of [ 2 H 8 ]arachidonic acid from the precursor tetraacetylene eicosatetraynoic procedures gave rise to substantial double-bond isomerization and isotopic scrambling, leading to mixtures that yielded after purification only small quantities of the desired product.
Mark A. Phillips +2 more
openaire +3 more sources
Glucagon and plasma arachidonic acid
Metabolism, 1965Abstract Previous work has shown the presence of a factor in the external pancreatic secretion of dogs distinct from the enzymes that affect plasma arachidonic acid. Removal of the exocrine factor by pancreatectomy or pancreatic duct ligation resulted in depression of arachidonic acid in all plasma lipid fractions which could not be corrected by ...
Raymond Caren, Lucille Corbo
openaire +3 more sources
Biologic Importance of Arachidonic Acid [PDF]
Archives of Internal Medicine, 1981 The most abundant prostaglandin precursor is arachidonic acid (or its precursor, linoleic acid). The isolation and identification of prostaglandin compounds in a particular tissue, knowledge of the biologic properties of these compounds, and the use of readily available inhibitors of the prostaglandin pathway by aspirin-like drugs constitute the main ...
openaire +2 more sources
Psoriasis and the arachidonic acid cascade
Journal of Dermatological Science, 1999Arachidonic acid (5.8,11,14-eicosatetraenoic acid C20:4, n-6) is released from the cell membrane by the action of phospholipases on membrane phospholipids. Metabolites of arachidonic acid, which are generically termed eicosanoids, including prostaglandins, thromboxane, leukotrienes and hydroxyeicosatetraenoic acids, have been implicated as mediators or
openaire +2 more sources
Vasoactivity of arachidonic acid epoxides
European Journal of Pharmacology, 1987Arachidonic acid (AA) can be metabolized to epoxides and their corresponding diols via the cytochrome P450 epoxygenase pathway. We have compared the vascular activity of four synthetically prepared epoxyeicosatrienoic acids, i.e. 5,6-, 8,9-, 11,12- and 14,15-EET (2-20 microM) on the isolated perfused rat tail artery.
Mairead A. Carroll +4 more
openaire +3 more sources