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Annual Review of Biochemistry, 1986
C YC LOO XYGENASE PRODUC TS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . 70 Prostaglandin Endoperoxide Synthase 70 Metabolism of the Prostaglandin Endoperoxides 71 P RODUC TS OF THE 12-LIPO XYGEN ASE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
P, Needleman +4 more
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C YC LOO XYGENASE PRODUC TS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . 70 Prostaglandin Endoperoxide Synthase 70 Metabolism of the Prostaglandin Endoperoxides 71 P RODUC TS OF THE 12-LIPO XYGEN ASE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
P, Needleman +4 more
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Preventive Medicine, 1987
Arachidonic acid metabolites can act as tumor promoters and can affect growth and metastases of tumors in three ways: (a) Prostacyclin inhibits and thromboxane facilitates platelet-tumor cell interactions and, thereby, tumor cell invasiveness; (b) the cytoprotective action of prostaglandins contributes to epithelial cell integrity and influences tissue
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Arachidonic acid metabolites can act as tumor promoters and can affect growth and metastases of tumors in three ways: (a) Prostacyclin inhibits and thromboxane facilitates platelet-tumor cell interactions and, thereby, tumor cell invasiveness; (b) the cytoprotective action of prostaglandins contributes to epithelial cell integrity and influences tissue
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Prostaglandins, Arachidonic Acid, and Inflammation
Science, 1980The enzymatic oxidation of arachidonic acid has been shown to yield potent pathological agents by two major pathways. Those of the prostaglandin (PG) pathway, particularly PGE2, have been implicated as inflammatory mediators for many years. The discovery and biological activities of thromboxane A2and prostacyclin as well as a destructive oxygen ...
F A, Kuehl, R W, Egan
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Arachidonic acid production by microorganisms
Biotechnology and Applied Biochemistry, 1992Arachidonic acid (AA) is a natural precursor of prostaglandins, thromboxanes, leukotrienes, prostacyclins, and a large group of C20 compounds which are of intrinsic medical interest. At present, the only source of AA is animal tissues. However, it is present in several microorganisms. This review describes the production of AA by microorganisms and its
P, Bajpai, P K, Bajpai
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Arachidonic acid aggregates neutrophils
Inflammation, 1979Arachidonic acid, but not several structurally similar fatty acids, stimulated neutrophils in suspension to aggregate; this effect was blocked by 5, 8, 11, 14-eicosatetraynoic acid, an inhibitor of arachidonic acid metabolism. Analagous to platelets, arachidonate may be a precursor of active metabolites which mediate neutrophil responses.
J T, O'Flaherty +3 more
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Renal Arachidonic Acid Metabolism
Annual Review of Physiology, 1984Renal prostaglandin synthesis has been the focus of extensive investigation during the past decade. This chapter reviews the cellular localization of renal arachidonic acid metabolism in view of the substantial recent progress in the isolation and culture of renal cell types.
M G, Currie, P, Needleman
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CHEMIEXCITATION IN THE ARACHIDONIC ACID CASCADE
Photochemistry and Photobiology, 1991Abstract—As investigated in neutrophils, the very weak luminescence accompanying the arachidonic acid cascade is associated with the lipoxygenase pathway. The emission is dramatically enhanced by energy transfer to chlorophylla. The number of chlorophyll molecules excited to the fluorescent state per oxygen consumed, (the S1/O2ratio), equal to the ...
A L, Nascimento, G, Cilento
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Arachidonic acid and colorectal carcinogenesis
Molecular and Cellular Biochemistry, 2003Colorectal carcinoma is a leading cause of cancer related death worldwide. This deadly disease advances through a series of clinical and histopathological stages, initiated by single crypt lesions to small benign tumors and finally to malignancy. Although some progress has been made in elucidating the formation of colorectal tumors at molecular/genetic
Raymond, Jones +4 more
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