Advanced Science, EarlyView.Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen +16 more
wiley +1 more source
Editorial Expression of Concern: Prevalence and risk factors for female sexual dysfunction among Egyptian women. [PDF]
Arch Gynecol ObstetIbrahim ZM, Ahmed MR, Ahmed WAS.
europepmc +1 more source
Advanced Science, EarlyView.This work establishes a standardized, high‐resolution spatial transcriptomics workflow for characterizing host responses to biomaterial implants. Using the 10× Xenium platform, the pipeline integrates spatial mapping, subclustering, and functional enrichment to resolve immune and stromal cell organization at single‐cell resolution, enabling ...
Alex H.P. Chan +7 more
wiley +1 more source
Efficacy evaluation and parametric study of the novel concave triple branched stent graft system based on hemodynamic analysis of first-in-man cases. [PDF]
Quant Imaging Med SurgCao X +8 more
europepmc +1 more source
In Situ Lipoprotein‐seeking Dye for in Vivo Real‐Time Imaging of Lipid Dysregulation Diseases
Advanced Science, EarlyView.This study develops lipoprotein‐seeking NIR‐II dyes that specifically bind circulating lipoproteins. These dyes form ultra‐stable complexes with endogenous lipoprotein, enabling real‐time, high‐contrast imaging of fatty liver and atherosclerotic plaques. Tunable binding kinetics allow customized imaging windows.
Yijing Du +6 more
wiley +1 more source
Mid-term Outcomes Following Primary Covered Stent Implantation in Supra-Aortic Arch Vessels for Atherosclerotic Occlusive Disease. [PDF]
Vasc Specialist IntSachsamanis G +5 more
europepmc +1 more source
Material‐Induced Nuclear Deformation Controls Chromatin Architecture in Adipose Stem Cells
Advanced Science, EarlyView.Tuning cell and cytoskeleton mechanics modulated nuclear shape and heterochromatin organization in ASCs. Distinct cytoskeletal architectures induced nuclear morphologies from oblate to prolate ellipsoids. Large elongated cells with a structured actin cap exhibited high nuclear strain, driving nuclear envelope deformation and heterochromatin ...
Carlo F. Natale +6 more
wiley +1 more source
Relationship between plantar fascia thickness in static standing and calf raise positions and the medial longitudinal arch height ratio in healthy adults. [PDF]
J Phys Ther SciShimizu R, Kimura N, Sato E, Yamaji T.
europepmc +1 more source
In Situ Characterisation of Hydrogels via Dynamic Interface Printing
Advanced Science, EarlyView.ABSTRACT Hydrogels have become pivotal materials for tissue engineering, robotics, biomedical devices, and sensing applications due to their diverse material compositions and tunable mechanical properties. While significant effort has focused on developing novel manufacturing approaches such as extrusion bioprinting and light‐based fabrication methods,
Callum Vidler +2 more
wiley +1 more source
Long-term outcomes of frozen elephant trunk for non-A non-B aortic dissection: a comparative analysis based on entry tear location. [PDF]
J Thorac DisJi Y +6 more
europepmc +1 more source