Results 1 to 10 of about 28,641 (215)

Sequence Analysis and Comparative Study of the Protein Subunits of Archaeal RNase P [PDF]

Biomolecules, 2016
RNase P, a ribozyme-based ribonucleoprotein (RNP) complex that catalyzes tRNA 5′-maturation, is ubiquitous in all domains of life, but the evolution of its protein components (RNase P proteins, RPPs) is not well understood.
Manoj P. Samanta, Stella M. Lai, Charles J. Daniels, Venkat Gopalan   +3 more
doaj   +2 more sources

Minimal Yet Powerful: The Role of Archaeal Small Heat Shock Proteins in Maintaining Protein Homeostasis [PDF]

Frontiers in Molecular Biosciences, 2022
Small heat shock proteins (sHsp) are a ubiquitous group of ATP-independent chaperones found in all three domains of life. Although sHsps in bacteria and eukaryotes have been studied extensively, little information was available on their archaeal homologs
Mousam Roy, Koustav Bhakta, Abhrajyoti Ghosh   +2 more
doaj   +2 more sources

Discovery of archaeal fusexins homologous to eukaryotic HAP2/GCS1 gamete fusion proteins [PDF]

Nature Communications, 2022
Sexual reproduction in eukaryotes involves gamete fusion, mediated by fusogenic proteins. Here, the authors identify fusogenic protein homologs encoded within mobile genetic elements in archaeal genomes, solve the crystal structure of one of the proteins,
David Moi, Shunsuke Nishio, Xiaohui Li, Clari Valansi, Mauricio Langleib, Nicolas G. Brukman, Kateryna Flyak, Christophe Dessimoz, Daniele de Sanctis, Kathryn Tunyasuvunakool, John Jumper, Martin Graña, Héctor Romero, Pablo S. Aguilar, Luca Jovine, Benjamin Podbilewicz   +15 more
doaj   +2 more sources

Uncovering the prevalence, key biogenesis enzymes, and biological significance of archaeal lipoproteins [PDF]

Nature Communications
Lipid-anchored proteins are integral components of cell surfaces. In bacteria, lipidation of proteins with a conserved lipobox motif ([L/V/I]−3 [A/S/T/V/I]−2 [G/A/S]−1 [C]+1) is catalyzed by prolipoprotein diacylglyceryl transferase (Lgt).
Yirui Hong, Kira S. Makarova, Andy A. Garcia, Rachel Xu, Friedhelm Pfeiffer, Paula V. Welander, Mechthild Pohlschroder   +6 more
doaj   +2 more sources

Supramolecular tholos-like architecture constituted by archaeal proteins without functional annotation. [PDF]

Sci Rep, 2020
Yagi-Utsumi M, Sikdar A, Song C, Park J, Inoue R, Watanabe H, Burton-Smith RN, Kozai T, Suzuki T, Kodama A, Ishii K, Yagi H, Satoh T, Uchiyama S, Uchihashi T, Joo K, Lee J, Sugiyama M, Murata K, Kato K.   +19 more
europepmc   +3 more sources

Evolutionary conservation of ubiquitin-like protein urmylation as revealed by URM1 gene shuffle from archaea to yeast [PDF]

Communications Biology
Urm1 from yeast is a unique ubiquitin-like protein with dual functionality. It has been shown to operate in tRNA thiolation and protein urmylation, combining features typical of bacterial sulfur carriers and classical ubiquitin-like modifiers.
Katharina Zupfer, Lars Kaduhr, Larissa Bessler, Mark Helm, Raffael Schaffrath   +4 more
doaj   +2 more sources

Comprehensive Bioinformatics Analysis of the Biodiversity of Lsm Proteins in the Archaea Domain

Microorganisms, 2023
The Sm protein superfamily includes Sm, like-Sm (Lsm), and Hfq proteins. Sm and Lsm proteins are found in the Eukarya and Archaea domains, respectively, while Hfq proteins exist in the Bacteria domain.
Gloria Payá, Vanesa Bautista, Mónica Camacho, Julia Esclapez, María-José Bonete   +4 more
doaj   +1 more source

Conserved and lineage-specific hypothetical proteins may have played a central role in the rise and diversification of major archaeal groups

BMC Biology, 2022
Background Archaea play fundamental roles in the environment, for example by methane production and consumption, ammonia oxidation, protein degradation, carbon compound turnover, and sulfur compound transformations.
Raphaël Méheust, Cindy J. Castelle, Alexander L. Jaffe, Jillian F. Banfield   +3 more
doaj   +1 more source

Remote Homology Detection Identifies a Eukaryotic RPA DBD-C-like DNA Binding Domain as a Conserved Feature of Archaeal Rpa1-Like Proteins

Frontiers in Molecular Biosciences, 2021
The eukaryotic single-stranded DNA binding factor replication protein A (RPA) is essential for DNA replication, repair and recombination. RPA is a heterotrimer containing six related OB folds and a winged helix-turn-helix (wH) domain.
Stuart A. MacNeill
doaj   +1 more source

The Archaeome’s Role in Colorectal Cancer: Unveiling the DPANN Group and Investigating Archaeal Functional Signatures

Microorganisms, 2023
Background and Aims: Gut microbial imbalances are linked to colorectal cancer (CRC), but archaea’s role remains underexplored. Here, using previously published metagenomic data from different populations including Austria, Germany, Italy, Japan, China ...
Nour El Houda Mathlouthi, Imen Belguith, Mariem Yengui, Hamadou Oumarou Hama, Jean-Christophe Lagier, Leila Ammar Keskes, Ghiles Grine, Radhouane Gdoura   +7 more
doaj   +1 more source