Results 1 to 10 of about 1,586,071 (235)

Specificity and Function of Archaeal DNA Replication Initiator Proteins

Cell Reports, 2013
Chromosomes with multiple DNA replication origins are a hallmark of Eukaryotes and some Archaea. All eukaryal nuclear replication origins are defined by the origin recognition complex (ORC) that recruits the replicative helicase MCM(2-7) via Cdc6 and ...
Rachel Y. Samson, Yanqun Xu, Catarina Gadelha, Todd A. Stone, Jamal N. Faqiri, Dongfang Li, Nan Qin, Fei Pu, Yun Xiang Liang, Qunxin She, Stephen D. Bell   +10 more
doaj   +6 more sources

Comprehensive analyses of archaeal viral genomes reveal genomic characteristics, divergence, and host interactions [PDF]

Microbiome
Background The ecological significance of bacteriophages has been extensively investigated, while the role of archaeal viruses across different environments remains poorly understood.
Chao Wei, Yaxiang Wang, Zhe Chen
doaj   +2 more sources

Discovery of archaeal fusexins homologous to eukaryotic HAP2/GCS1 gamete fusion proteins

Nature Communications, 2022
Sexual reproduction in eukaryotes involves gamete fusion, mediated by fusogenic proteins. Here, the authors identify fusogenic protein homologs encoded within mobile genetic elements in archaeal genomes, solve the crystal structure of one of the proteins,
David Moi, Shunsuke Nishio, Xiaohui Li, Clari Valansi, Mauricio Langleib, Nicolas G. Brukman, Kateryna Flyak, Christophe Dessimoz, Daniele de Sanctis, Kathryn Tunyasuvunakool, John Jumper, Martin Graña, Héctor Romero, Pablo S. Aguilar, Luca Jovine, Benjamin Podbilewicz   +15 more
doaj   +2 more sources

Predicting membrane protein localization by deep learning on structure and chemistry. [PDF]

Protein Sci
Abstract It has been known since at least the 1980's that the structure and chemistry of membranes and membrane proteins are matched. Exploiting this fact, a graph neural network model of proteins was trained on experimentally determined membrane protein structures to predict the native membrane environment of transmembrane domains from their structure.
Pokhrel B, Munley C, Pedraza M, Lyman E.
europepmc   +2 more sources

Universal and Lineage-Specific Patterns in the Distribution of ECOD Domain Homology Groups Across Superkingdoms. [PDF]

Proteins
ABSTRACT Proteins are built from modular domains that serve as fundamental units of structure and evolution. While individual domains have been extensively cataloged, their collective distribution across the lineages of life has remained poorly resolved.
Guo R, Pei J, Zhang J, Cong Q, Grishin NV, Schaeffer RD.   +5 more
europepmc   +2 more sources

Asgard archaea: have we found our microbial ancestors? [PDF]

The EMBO Journal
The discovery of Asgard archaea about a decade ago has greatly reshaped our understanding of archaeal evolution and the origin of eukaryotes. Asgards are currently thought to be the closest prokaryotic relatives of eukaryotes and to represent the ...
Christa Schleper, Thiago Rodrigues-Oliveira   +1 more
doaj   +2 more sources

Histone diversity in the archaeal domain of life [PDF]

Nature Communications
Two-thirds of all archaea encode histones, proteins that are ubiquitously used to structure chromatin in eukaryotes. Archaeal histone sequences are less conserved than their eukaryotic counterparts, and insight into how they structure DNA is limited to a
Shawn P. Laursen, Karolin Luger
doaj   +2 more sources

Minimal Yet Powerful: The Role of Archaeal Small Heat Shock Proteins in Maintaining Protein Homeostasis

Frontiers in Molecular Biosciences, 2022
Small heat shock proteins (sHsp) are a ubiquitous group of ATP-independent chaperones found in all three domains of life. Although sHsps in bacteria and eukaryotes have been studied extensively, little information was available on their archaeal homologs
Mousam Roy, Koustav Bhakta, Abhrajyoti Ghosh   +2 more
doaj   +1 more source

Comprehensive Bioinformatics Analysis of the Biodiversity of Lsm Proteins in the Archaea Domain

Microorganisms, 2023
The Sm protein superfamily includes Sm, like-Sm (Lsm), and Hfq proteins. Sm and Lsm proteins are found in the Eukarya and Archaea domains, respectively, while Hfq proteins exist in the Bacteria domain.
Gloria Payá, Vanesa Bautista, Mónica Camacho, Julia Esclapez, María-José Bonete   +4 more
doaj   +1 more source

Conserved and lineage-specific hypothetical proteins may have played a central role in the rise and diversification of major archaeal groups

BMC Biology, 2022
Background Archaea play fundamental roles in the environment, for example by methane production and consumption, ammonia oxidation, protein degradation, carbon compound turnover, and sulfur compound transformations.
Raphaël Méheust, Cindy J. Castelle, Alexander L. Jaffe, Jillian F. Banfield   +3 more
doaj   +1 more source