Results 191 to 200 of about 7,911 (265)

Molecular phenotypes and spatial archetypes: A new framework for cancer-associated fibroblasts. [PDF]

Cancer Cell
Liu Y, Chen X, Dai Y, Jia Y, Kieffer Y, Xie L, Zhou Z, Tyler L, Kim AC, Biffi G, Krishnamurty AT, Mechta-Grigoriou F, Scherz-Shouval R, Sherman MH, Turley SJ, Wang L, Huang H.   +16 more
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Acute hypoxemic respiratory failure: from static severity to trajectory-based phenotyping. [PDF]

Intensive Care Med
Pensier J, Alipanah-Lechner N, Bauer PR.
europepmc   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Archetypes of Binocular Visual Field Loss and Their Impact on Vision-Related Quality of Life in Glaucoma Patients. [PDF]

Invest Ophthalmol Vis Sci
Gazanchian M, Nejad A, Crabb DP, Montesano G, Jansonius NM.   +4 more
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Unsupervised Clustering for POAG Phenotyping. [PDF]

Invest Ophthalmol Vis Sci
Puspa PA, Parmar UPS, Sekimitsu S, Moradi M, Rossin EJ, Friedman D, Elze T, Zebardast N.   +7 more
europepmc   +1 more source

Context-specific life cycle emissions pathways for EU buildings and construction. [PDF]

Nat Commun
Alaux N, Bechstedt N, Zhong X, Mastrucci A, Ramon D, Steinberger-Maierhofer D, Allacker K, Passer A, Röck M.   +8 more
europepmc   +1 more source

The Human Face of Surgery: How Surgeon Attitude Shapes Patient Expectations and Recovery. [PDF]

J Patient Exp
Guilbault R, Bojko A.
europepmc   +1 more source