Results 61 to 70 of about 97,500 (274)

Documentul istoric depre creştinătate. Cronica medievală: analiză arhetipală [PDF]

open access: yesRevista de Istorie și Teorie Literară, 2013
What does colliding with worlds other than their own mean for the Christians in the Middle Ages? Which are the phrases defining the Christian – Heathen opposition?
Lavinia Bănică
doaj  

Report on the EHCR (Deliverable 26.1) [PDF]

open access: yes, 2005
The challenge of richly interpreting electronic health information, in order to populate EHR instances with suitable terms, to provide decision support in the care of individuals, to identify suitable patients for teaching or clinical trials ...
Kalra, D.
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Geographic Information System-Based Stock Characterization of College Building Archetypes in Saudi Public Universities

open access: yesBuildings
Building archetypes are essential for advancing architectural theory and energy modeling, providing a foundation for scalable assessments of building performance and sustainability worldwide.
Azzam H. Alosaimi
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Achieving IT diffusion within the fragments: an IT culture perspective [PDF]

open access: yes, 2013
Many organizations still fail to make a return from the huge investments they make in implementing complex Information Technology (IT). This is usually due to cultural forces that inhibit the level of usage required to facilitate IT Diffusion.
Abubakre, M, Coombs, C, Ravishankar, MN
core  

A conceptual framework for circular design [PDF]

open access: yes, 2016
Design has been recognised in the literature as a catalyst to move away from the traditional model of take-make-dispose to achieve a more restorative, regenerative and circular economy.
Charnley, Fiona   +3 more
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

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