Results 61 to 70 of about 23,461 (309)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Understanding developer security archetypes [PDF]

, 2021
As software systems penetrate our everyday lives, security has risen to be a key concern. Despite decades of research leading to new tools and practices for writing secure code, achieving security as a key attribute remains highly challenging. We observe
Klaas-Jan Stol, Stol, Klaas-Jan, Roedig, Utz, Ita Ryan, Ryan, Ita, Utz Roedig   +5 more
core   +1 more source

Pareto task inference analysis reveals cellular trade-offs in diffuse large B-Cell lymphoma transcriptomic data

Frontiers in Systems Biology
One of the main challenges in cancer treatment is the selection of treatment resistant clones which leads to the emergence of resistance to previously efficacious therapies.
Jonatan Blais, Julie Jeukens
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

RESTAURANTE UNIVERSITÁRIO DA UFPE: UMA ABORDAGEM SISTÊMICA

Revista Gestão Universitária na América Latina, 2018
This study aims to analyze a problem situation of the university restaurant of the Federal University of Pernambuco regarding the limited capacity of the service in the light of systems theory.
Carla Ionara Xavier da Silveira Cardoso, Danubia Paula da Silva Menezes, André Melo de Souza, Roberta Macedo Baudel, Dinara Leslye Macedo e Silva Calazans   +4 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Mythological narratives of Japanese animation: the memory of the collective unconscious in the culture of consumerism

Cхід
The article explores the use of mythological narratives in Japanese animation as part of collective memory in the context of consumer culture. The author analyses symbolic and archetypal images in popular animated works such as Spirited Away, Gyakkyō ...
Roman Vorobei
doaj   +1 more source

Documentul istoric depre creştinătate. Cronica medievală: analiză arhetipală [PDF]

Revista de Istorie și Teorie Literară, 2013
What does colliding with worlds other than their own mean for the Christians in the Middle Ages? Which are the phrases defining the Christian – Heathen opposition?
Lavinia Bănică
doaj  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source