Results 131 to 140 of about 585,747 (341)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
ALFRED-DONAT AGACHE URBAN PROPOSAL FOR COSTA DO SOL. FROM THE TERRITORY TO THE CITY. [PDF]
, 2013 This paper reviews the development of Costa do Sol, as planned by architect urbanist Alfred-Donat Agache, for Lisbon Region in Portugal. The Plano Expansão Região Oeste de Lisboa (1934-1936) prepared by Agache and requested by Portuguese Minister of ...
André, Paula +2 more
core
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
FRANK LLOYD WRIGHT’S SAMARA, ACOUSTICAL SOLUTIONS OF THE 1950’S
Archives of Acoustics, 2014 The problem of environmental noise pollution concerns many Americans whose homes are near highways and busy streets. A famous American Architect, Frank Lloyd Wright, designed houses that have been noted for their architectural splendor and alleged ...
R. J. PANUSZKA, K. A. PANUSZKA
doaj
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Castle restoration in Slovakia past and present (História a súčasnosť pamiatkových obnov hradov na území Slovenska) [PDF]
Muzeológia a Kultúrne Dedičstvo, 2016 There are approximately 300 castles in Slovakia, 109 of which have the status of nationally cultural monument (NKP) and as of today, 55 of these have been restored or are currently undergoing restoration.
Zuzana Ondrejková
doaj