Results 261 to 270 of about 585,747 (341)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Optimizing syphilis screening in South Africa: efficacy of the iStatis antibody test in point-of-care settings amid reinfection challenges. [PDF]

AIDS Res Ther
Mahomed S, Madurai S, Nair S, Cawood C, Eades J, Wang D, Subramanian A.   +6 more
europepmc   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Disembodied creativity in generative AI: <i>prima facie</i> challenges and limitations of prompting in creative practice. [PDF]

Front Artif Intell
Casacuberta D, Guersenzvaig A.
europepmc   +1 more source

Towards a Public Architectural History: Collective-Use Facilities and Community Engagement in Portugal and Spain. [PDF]

Int Public Hist
Agarez RC, Mehnert Pascoal A, Herrera-Pineda I.   +2 more
europepmc   +1 more source

The Diagnostic Trap: When PSA Results Mislead - A Case Report. [PDF]

Case Rep Oncol
Birk-Korch JB, Vestergaard Madsen C, Kromann-Tofting T, Ellegaard Mortensen J, Madsen JS, Soerensen PD.   +5 more
europepmc   +1 more source

Multicenter 30-Year Data on the 4-Mg Intravenous Dexamethasone Suppression Test in the Diagnosis of Cushing Syndrome. [PDF]

J Endocr Soc
Jung C, Derbyshire MM, Jauhar N, Bennett D, Topliss DJ, Gogna R, Markovic N, Burgess JR, Inder WJ.   +8 more
europepmc   +1 more source

From Challenges to Innovations: Expert Insights in Pediatric Healthcare Design. [PDF]

HERD
Sathyanarayanan H, Caldas L.
europepmc   +1 more source