Results 101 to 110 of about 568,927 (343)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Exploring the Link between Job Satisfaction and Productivity in Architectural Offices

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi
Job satisfaction is an important factor that directly affects an employee's productivity. The relationship between job satisfaction and productivity is a critical factor in many professions, including architecture.
Yasemin Erbil, Yiğit Can Yardımcı
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Twenty questions about design behavior for sustainability, report of the International Expert Panel on behavioral science for design [PDF]

, 2019
How behavioral scientists, engineers, and architects can work together to advance how we all understand and practice design—in order to enhance sustainability in the built environment, and beyond.https://www.nature.com/documents ...
Akerlof, Karen, Andrews, Clinton, Attari, Shahzeen, Aurisicchio, Marco, Bansal, Tima, Barnett, Michaela, Caroll, Tomeka, Castilla-Rho, Juan, Chen, Nina, Chon, Jinhyung, Cohen, Nicki, Constantino, Sara, Contestabile, Monica, Domanski, Jeff, Ebers, Anna, Farr, Doug, Fedirko, Lina, Ferraro, Paul, Fischer, Eleni, Fischhoff, Baruch, Fischhoff, Maya, Geppner, James, Gero, John, Gonzalez, Richard, Gordon, Bethany, Hancock, Patrick, Henry, Marisa, Hernandez, Morela, Johnson, Eric, Kantenbacher, Joe, Lotz, Leidy, MacDonald, Erin, Madhavan, Guru, Malak, Richard, Mazar, Nina, Meggers, Forrest, Miniard, Deidra, Owsik, Catherine, Pearson, Adam, Pickering, John, Preston, Stephanie, Rench-McCauley, Dave, Schmidt, Ruth, Shealy, Tripp, Sherman, Erin, Shyamsundar, Priya, Steg, Linda, Stenger, Katelyn, Strahilevitz, Michael, Thomas, John, Torre, Jianna, Townsend, Allen, Tsoulou, Ioanna, Ulrich, Elaine, Voinov, Alexey, Vuppuluri, Richa, Weber, Elke, Weber, Shana, Welch, Sarah, Wilcoxen, Stephanie, Wylie, Caitlin, Zeeuw van der Laan, Anouk, Zeiske, Nadja, Zong, Michelle   +63 more
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

The humanitarian-architect divide

Forced Migration Review, 2017
Humanitarians and architects can fail to find a common language, characterising each other in schematic terms. It is time to bridge the divide and encourage greater collaboration between these professions.
Tom Scott-Smith
doaj  

In Defiance of a Stylistic Stereotype: British Crematoria, Architecture, Design and Landscape [PDF]

, 2006
This paper presented a new critical reading of the crematorium, rendered ‘invisible’ by the taboo surrounding death and provided the first opportunity to disseminate this research to an international audience.
Grainger, Hilary J.
core