Results 111 to 120 of about 430,746 (304)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Global experts 'off radar' [PDF]
, 2014 This issue of ABE Journal, which takes inspiration from a 2008 conference session as well as from the many conversations that took place within one of the working groups of the European funded COST-action “European Architecture beyond Europe,”1 seeks to ...
De Raedt, Kim, Lagae, Johan
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
['Sustainability and Modernism: Design Research at Cornell NYC']
Docomomo Journal, 2011 Ilana Judah, Daniel Kaplan
doaj +3 more sources
Security of tenure in the urban context
Forced Migration Review, 2017 Addressing the lack of secure tenure and the risk of forced eviction is one of the defining characteristics of urban shelter response.
Neil Brighton +2 more
doaj
Copyright issues on the protection of architectural works and designs [PDF]
Architects and engineers depend on copyright law to protect their original works. Copyright protection is automatic once a tangible medium of expression in any form of an innovative material, conforming the Copyright Designs and Patents Act 1988, is ...
Denoncourt, J, Mann, Phebe
core
Software engineering challenges: Achieving zero carbon buildings by 2019 [PDF]
, 2010 The planet Earth is warming up. There is an urgent need to reduce greenhouse gas emissions. Buildings account for almost 50% of UK carbon dioxide emissions.
Hetherington, Robina +2 more
core
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Appropriating buildings to house refugees: Berlin Tempelhof
Forced Migration Review, 2017 As European cities continue to co-opt existing buildings to use as refugee shelters, the inherent spatial characteristics of these structures present significant challenges to the authorities that select the sites and to those who must reside in them.
Toby Parsloe
doaj
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source