Results 111 to 120 of about 568,927 (343)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

The world turned upside-down : architects as subcontractors in design-and-build contracts [PDF]

open access: yes, 2008
The traditional role of the Architect on UK building projects is well-known and has been the subject of much study and comment. However, recent surveys indicate that design-and-build arrangements now exceed traditional procurement in terms of their share
Greenwood, David   +2 more
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

A camp redefined as part of the city

open access: yesForced Migration Review, 2017
Was what was built at La Linière in Grand-Synthe in northern France a traditional refugee camp or a new kind of urban district?
Cyrille Hanappe
doaj  

Fiscal federalism: US history for architects of Europe's fiscal union [PDF]

open access: yes
Ever since first the blueprints for monetary union in Europe were drawn up, the United States, considered as a collection of individual states or regions, has served as a benchmark for assessing its feasibility and evaluating alternative policy options ...
C. Randall Henning, Martin Kessler
core   +1 more source

Material Considerations in Architectural Design: A Study of the Aspects Identified by Architects for Selecting Materials [PDF]

open access: yes, 2009
Material selection in architecture is not only about choosing the strongest, cheapest, or most obvious materials available. Architects also choose warm, formal, functional, or local materials for buildings.
Wastiels, Lisa, Wouters, Ine
core  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Project report. A subtropical urban community, investigating medium to high density residential typologies by Design Charrette [PDF]

open access: yes, 2009
The Centre for Subtropical Design at QUT, in partnership with the Queensland Government and Brisbane City Council, conducts research focused on 'best practice' outcomes for higher density urban living environments in the subtropics through the study of ...
Kennedy, Rosemary
core   +4 more sources

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