Results 61 to 70 of about 19,793 (265)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Perestroika (1987–1999)

Проект Байкал, 2015
After Brezhnev’s death, starting from 1983, there were troublesome times in Russia. At first the senile secretaries general came and passed away, making ‘a funeral parade’, and then Gorbachev’s perestroika started.
Vladimir Stegaylo, Alexey Buynov, Nikolai Zhukovsky, Sergey Demkov, Natalya Sherstova   +4 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Operational performance and environmental satisfaction survey of a university building with large learning commons

Journal of Asian Architecture and Building Engineering
Learning Commons is being actively implemented in the design of university buildings to encourage diverse learning. Because the usage patterns of Learning Commons are different from those of regular classrooms, this design trend also has a significant ...
Yuma Tokuwaki, Takeru Kamide, Satoshi Hirakawa, Jun Maruyama, Kyosuke Hiyama   +4 more
doaj   +1 more source

The Golden Age (1975–1986)

Проект Байкал, 2015
The Institute had grown up by its tenth anniversary. It had become more significant in the development policy of Irkutsk and the Irkutsk region. Party officials had to reckon with the Institute.
Andrey Bokov, Yurii Berzhinsky, Alexander Kolesnikov, Vladimir Stegaylo, Nikolai Zhukovsky, Victoria Astrakhantseva, Alexander Studennikov   +6 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

International Architecture News

Проект Байкал
The news section presents the International Union of Architects (UIA) President Regina Gontier’s message for 2025, in which she encourages architects to strive to improve people’s well-being and quality of life through resilient architecture.
Анна Григорьева
doaj   +1 more source