Results 171 to 180 of about 19,426 (264)

From Data Stewardship to Model Stewardship: Extending Governance Frameworks for AI Era Health Data Use. [PDF]

J Med Internet Res
Rozenblit L, Labkoff S, Safran C.
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Editorial: Circular RNAs: from anomalies to cellular regulators. [PDF]

Front Genet
Barbagallo D, Chianese R, Manfrevola F.
europepmc   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Where design meets biology: an interview on SPIKA, a prototype for microbe-mediated architecture. [PDF]

Commun Biol
europepmc   +1 more source

Cardiac macrophages at the crossroads of inflammation, memory, and repair. [PDF]

Immunohorizons
Chen Y.
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Architects of folding, editors of immunity: the strategic use of <i>N</i>-glycans in vaccine design. [PDF]

Front Immunol
Orioli S, Idrovo-Hidalgo T, Martinez Saucedo MLA, D'Alessio C.   +3 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Viral architects of the deep biosphere: reshaping the framework of sedimentary biogeochemistry. [PDF]

Appl Environ Microbiol
Wang C, Sun C.
europepmc   +1 more source