Results 41 to 50 of about 124,140 (299)

Renovation of Kiyotsu Gorge Tunnel—A Case Study on the Effect of the Combination of Visual Information and Environmental Grade in a Sequential Space on Human Psychological Response

open access: yesJapan Architectural Review
This project is based on the hypothesis that the combination of visual information and environmental grades—such as airflow and temperature—in a uniform, sequential space can influence psychological responses.
Yosuke Hayano   +3 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Politi og arkitekters forebyggingslogikker: Forståelser av kriminalitetsforebyggende arbeid i offentlige rom

open access: yesNordisk Tidsskrift for Kriminalvidenskab, 2020
This article focuses on crime prevention through architecture, environmental design and other situational modifications to public space. Today’s crime control is characterized by a continuously expanding focus on prevention and the proliferation of new ...
Marina Hiller Foshaugen
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Understanding the Legendary Sound Environment in the Lobby of Hotel Okura Tokyo

open access: yesApplied Sciences, 2020
The main lobby of Hotel Okura Tokyo has a good reputation for its sound environment, which affects the conversations of its users. We assumed that the lobby’s reputation was related to its speech intelligibility.
Ryoko Nojima   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Learning from school buildings: energy efficiency and user comfort in Metro Vancouver elementary schools

open access: yesFACETS
In this study, schools built after 2000 in Metro Vancouver, Canada, showed an encouraging trend towards lower carbon emissions and energy use intensity. In 17 case studies, heat pumps, decentralized ventilation systems, and higher glazing-to-wall ratios ...
Amalie Lambert   +3 more
doaj   +1 more source

La recherche sur les acteurs de la fabrication de la ville : coulisses et dévoilements

open access: yesTerritoire en Mouvement, 2019
In urban research, the analysis of actors and manufacturing processes in the city has an intermittent presence and visibility. After the wave of Marxist-inspired works on the production of the capitalist city, circumscribed in the 1970s, then the ...
Véronique Biau
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Home - About - Disclaimer - Privacy