Results 51 to 60 of about 1,152,086 (290)
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source
FEM shakedown analysis of structures under random strength with chance constrained programming
Direct methods, comprising limit and shakedown analysis, are a branch of computational mechanics. They play a significant role in mechanical and civil engineering design.
Ngoc Trinh Tran +6 more
doaj +1 more source
Problem based learning in architectural education [PDF]
There is limited published research and discussion on pedagogical approaches in architectural education. Problem (or Project) Based Learning is used successfully in other professional disciplines, and, consequently, there have been attempts to utilise ...
Bridges, Alan
core
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
KARGIN VE MEŞELİ’DE YER ALAN ALEVİ YAPILARI [THE STRUCTURES OF ALEVİ IN KARGIN AND MEŞELİ]
Günümüzde Alevilik daha çok inanç, kültür veya siyaset odaklı çalışma konusu olmaktadır. Ancak özellikle inanç yönü ele alınırken ritüellerin gerçekleştiği mekânlar ilgili araştırmaların az sayıda olduğu görülmektedir.
Mürüvet Harman
doaj
The paper provides a new synthesis method of multiple attribute decisions (SyMAD-3 – Synthesis of Multiple Attribute Decisions using three methods) intended for combining multi-stage and multiple attribute decisions into a single common estimate.
Ruta Simanaviciene +2 more
doaj +1 more source
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
L'histoire assassinée. Manfredo Tafuri and the architecture of the present [PDF]
In recent years the work of Italian architectural historian Manfredo Tafuri has attracted a lot of interest in the world of architectural theory and practice.
Stoppani, T
core
Resolving Architectural Mismatches of COTS Through Architectural Reconciliation [PDF]
The integration of COTS components into a system under development entails architectural mismatches. These have been tackled, so far, at the component level, through component adaptation techniques, but they also must be tackled at an architectural level
C. Hofmeister +7 more
core +3 more sources
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source

